东南大学学报（英文版）2004，Vol.20Issue(1)：59-61,3.
一种制备D-缬氨酸的新方法
New method for preparation of D-valine
摘要
Abstract
A method for preparing D-valine from L-valine by racemization and chemical resolution is presented. The resolving reagent, D-2, 3-dibenzoyl tartaric acid was obtained by hydrolyzation of D-2, 3-dibenzoyl tartaric anhydride prepared by reaction of benzoyl chloride with D-tartaric acid. DL-valine was prepared by racemization of L-valine in the presence of aldehyde in a medium of acetic acid at 100 to 110 ℃ for 3 h. In the presence of mineral acid, reaction of D-2, 3-dibenzoyl tartaric acid with DL-valine formed diastreroisomeric salts at 84 to 95 ℃. Salt composed of D-2, 3-dibenzoyl tartaric acid and D-valine precipitated when the diastreroisomeric salts mixtures were cooled to 15 ℃. The salt was reacted with base giving D-valine with yield of 70% to 80% and optical purity of over 98%.关键词
L-缬氨酸/消旋化/化学拆分/D-缬氨酸Key words
L-valine/racemization/chemical resolution/D-valine分类
化学化工引用本文复制引用
徐海青,蒋立建,张征林,未本美..一种制备D-缬氨酸的新方法[J].东南大学学报（英文版）,2004,20(1):59-61,3.
