南京医科大学学报（英文版）2006，Vol.20Issue(1)：59-62,4.
Expression of c-kit receptor in peripheral blood mononuclear cells in patients with systemic lupus erythematosus
Expression of c-kit receptor in peripheral blood mononuclear cells in patients with systemic lupus erythematosus
Maihua Hou 1Lingyun Sun 2Xinzheng Lu3
作者信息
- 1. Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029
- 2. Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008
- 3. Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
- 折叠
摘要
Abstract
Objective: To determine the expression of c-kit receptor in peripheral blood mononuclear cells (PBMCs) in patients with systemic lupus erythematosus (SLE), and analyze the relationship between the c-kit expression level of PBMCs and clinical parameters. Methods: Peripheral blood mononuclear cells in 47 patients with SLE and 21 healthy volunteers were collected. Expression of c-kit mRNA in PBMCs were determined with reverse transcription-polymerase chain reaction (RT-PCR). The protein of c-kit receptor (CDll7) in PBMCs was measured by flow cytometry. Results: Expression of c-kit receptor protein and mRNA in patients with active or inactive SLE ( n = 47) were significantly higher than those in controls. The c-kit receptor of PBMCs in SLE patients were significantly higher than those in healthy controls ( n = 21), the c-kit receptor of PBMCs in active patients ( n = 27) were significantly higher than those in inactive patients ( n = 20) and there was no significant difference was found between patients with inactive SLE and healthy controls(P＞0.05). The c-kit receptor of PBMCs in SLE have significant association with activity index. Conclusion: Production of c-kit receptor is aberrantly increased in PBMCs in patients with SLE. C-kit receptor might be more closely related to the clinical parameters in SLE patients,which might reflect the clinical status of SLE patients.关键词
systemic lupus erythematosus/c-kit receptor/peripheral blood mononuclear cellsKey words
systemic lupus erythematosus/c-kit receptor/peripheral blood mononuclear cells分类
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Maihua Hou,Lingyun Sun,Xinzheng Lu..Expression of c-kit receptor in peripheral blood mononuclear cells in patients with systemic lupus erythematosus[J].南京医科大学学报（英文版）,2006,20(1):59-62,4.
