中国临床康复2004，Vol.8Issue(27)：5992-5993,2.
天麻钩藤饮对肝阳上亢型原发性高血压患者血浆内皮素的影响
Effects of tianma gouteng decoction on the plasma endothelin of patients with primary hypertension of hyperactivity of the liver yang
摘要
Abstract
AIM:To investigate the effects of tianma gouteng decoction to the blood pressure and plasma endothelin of patients with primary hypertension in order to provide theoretic basis for treatment and rehabilitation. METHODS:All the cases were chosen from hospitalized patients or outpatients of Xiangya Hospital of Central South University during September 2001 to September 2002.They were randomly divided into two groups:52 cases in tianma gouteng group with 41 males and 11 females,mean age was(55± 4) years old.Selecting criteria:Meet the diagnostic classification standard of WHO edited in 1999 and the differentiation standards of hyperactivity of liver yang.Exclusive criteria:Patients with coronary heart disease,cerebral apoplexy,renal insufficiency and III level hypertension were excluded.Tianma gouteng group was administrated with tianma gouteng decoction while control group was provided nitrendipine for 4 weeks.The changes of blood pressure and plasma endothelin were observed after 4 weeks treatment to both groups. RESULTS:The blood pressure of both tianma gouteng group(t=2.400,P< 0.05)and control group(t=2.210,P< 0.05) was remarkably reduced.The plasma endothelin level before treatment[(87.96± 13.57) ng/L] was much higher than that after treatment [(56.21± 14.00) ng/L] in tianma gouteng group(t=2.651,P< 0.01). CONCLUSION:Tianma gouteng can greatly reduce the blood pressure of patients with hypertension.The possible mechanism of it is due to the decrease of endothelin level.关键词
天麻钩藤饮/药理学/高血压/中药疗法/内皮素分类
医药卫生引用本文复制引用
林展增,邢之华,蔡昌龙,谭海彦,张臣..天麻钩藤饮对肝阳上亢型原发性高血压患者血浆内皮素的影响[J].中国临床康复,2004,8(27):5992-5993,2.基金项目
湖南省卫生厅中医药科研基金资助 (202060) （202060）
