中国临床康复2004，Vol.8Issue(27)：5998-5999,2.
缺氧缺血性脑病新生儿纳洛酮治疗前后血浆β-内啡肽的改变
Alteration of serum beta-endorphin before and after the treatment of naloxone in neonates with hypoxic-ischemic encephalopathy
唐兰芬 1陈铭珍 1孟琼 1苏赞彩 1揭育丽2
作者信息
- 1. 广东医学院附属医院儿科,广东省湛江市,524001
- 2. 广东医学院附属医院同位素科,广东省湛江市,524001
- 折叠
摘要
Abstract
BACKGROUND:Cerebral hypoxic ischemia could activate serials of biologic reactions and induce the changes in the expressions of multiple substances in neurons,which thereby further mediates injuries in brain tissues. There are few researches at present regarding to whether β-endorphin participates in the therapeutic process of naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy(HIE). OBJECTIVE:To observe the alteration of serum beta-endorphin(β-endorphin) before and after the treatment of naloxone for the discussion of the protective effects of naloxone in neonatal HIE. DESIGN:A non-randomised controlled trial based on diagnosis. SETTING and PARTICIPANTS:A total of 38 mature infants with HIE were selected into HIE group from the department of neonate of Guangdong Medical University Affiliated Hospital during October 1996 to October 1997 including 26 male and 12 female cases.25 normal mature neonates were selected into normal group from the Infant Room of Obstetrical Department, Affiliated Hospital of Guangdong Medical College,including 15 male and 10 male subjects. INTERVENTIONS:Serum β-endorphin was detected within 72 hours after born(acute stage,before therapy) and at 7 to 10 days(recovery period) respectively in 38 HIE neonates, and within 72 hours after born in 25 normal neonates as well.38 HIE neonates were randomly allocated into naloxone group and non-naloxone group for the observation of the clinical therapeutic effectiveness and the alteration of serum β-endorphin before and after therapy.Main outcome measures: serum content of β-endorphin in neonates of each group. RESULTS:Serum β-endorphin significantly elevated at acute stage in 38 HIE neonates compared with that of 25 normal neonates[(620.35± 140.92) ng/L,(373.70± 146.69) ng/L,t=6.16,P< 0.01],but no significant difference in recovery period between HIE and normal neonates [(335.34± 160.37) ng/L,(373.70± 146.69) ng/L,P >0.05].There was no significance in the comparison of differences of serum β-endorphin before and after therapy between naloxone group and non-naloxone group; however,naloxone could reduce the course of the disease and relieve the clinical symptoms of neonates with severe HIE as well. CONCLUSION:β-endorphin participates in HIE pathophysiologic process and naloxone has certain therapeutic effects in the treatment of HIE.关键词
脑缺血/病理生理学/脑缺氧/病理生理学/婴儿,新生,疾病/β-内啡肽/纳洛酮分类
医药卫生引用本文复制引用
唐兰芬,陈铭珍,孟琼,苏赞彩,揭育丽..缺氧缺血性脑病新生儿纳洛酮治疗前后血浆β-内啡肽的改变[J].中国临床康复,2004,8(27):5998-5999,2.
