中华医学杂志（英文版）2003，Vol.116Issue(4)：605-608,4.
Clinical observation of serum IL-18, IL-10 and sIL-2R levels in patients with chronic hepatitis C pre- and post antiviral treatment
Clinical observation of serum IL-18, IL-10 and sIL-2R levels in patients with chronic hepatitis C pre- and post antiviral treatment
贾红宇 1杜杰 2朱思和 3马英骥 3蔡华枫3
作者信息
- 1. The Immunological Department, Institute of Infectious Diseases of the First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, China
- 2. The Department of Pharmacology of Harbin Medical University, Harbin 150086, China
- 3. The Department of Infectious Diseases of the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
- 折叠
摘要
Abstract
Objective To discuss the roles of serum interleukin-18 (IL-18), interleukin-10 (IL-10) and soluble interleukin-2R (sIL-2R) in the pathogenesis of chronic hepatitis C and to observe the effects of interferon (IFN) on the above- mentioned serum cytokines. Methods The levels of above- mentioned cytokines were detected in 10 healthy individuals, 24 asymptomatic hepatitis virus C (HCV) carriers and 27 patients with chronic hepatitis C ( before and after IFN treatment) using enzyme linked immunosorbent assay (ELISA). Results The levels of the cytokines in patients with chronic hepatitis C are higher than in healthy people (P<0.05) and in asymptomatic HCV carriers(P<0.05). The values of the cytokines show a significant positive correlation to ALT (P<0.05). Levels of tested cytokines decreased observably after IFN treatment (P<0.05). The grades of the serum levels for sIL-2R and IL-10 before IFN treatment (from high to low) were categorized accordingly: non-response group＞ partial- response group ＞complete- response group (P<0.05). Conclusions The tested cytokines co-participate in the pathogenesis of chronic hepatitis C, and can be used to evaluate the effect of IFN on the immune state of organisms. Furthermore, sIL-2R and IL-10 are important for predicting the anti-viral efficacy of IFN.关键词
IL-18/IL-10/sIL-2R/viral hepatitis C/antiviral treatmentKey words
IL-18/IL-10/sIL-2R/viral hepatitis C/antiviral treatment分类
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贾红宇,杜杰,朱思和,马英骥,蔡华枫..Clinical observation of serum IL-18, IL-10 and sIL-2R levels in patients with chronic hepatitis C pre- and post antiviral treatment[J].中华医学杂志（英文版）,2003,116(4):605-608,4.
