西北国防医学杂志2001，Vol.22Issue(1)：60-62,3.
血清透明质酸、层粘连蛋白及IV型胶原在肝纤维化
及肝癌中的变化分析
Serum hyalurionic acid，laminin and type IV collagen in patients with hepatic fibrosis and primary liver cancer
邓芝云 1张方信 1于兰 1高福兴 1吕同德1
作者信息
- 1. 兰州军区兰州总医院，甘肃 兰州 730050
- 折叠
摘要
Abstract
Objective:To study the relationship between serum hyalurionic acid(HA),laminin(LN),type IV collagen(IV-C) and hepatic fibr osis or primary liver cancer(PLC).Methods:Serum HA,L N and IV-C were detected in 65 chronic viral hepatitis(CVH),108 posthepatitic c irrhosis(PHC) and 51 PLC patients by radioimmunoassay.Results:The serum components in CVH,PHC and PLC patients were notably higher than those in normal controls (NC),and these components in PHC and PLC patients were also significantly higher than those in CVH patients.The highest sensitivity and accuracy were in HA(84.9％ and 79.8％),but the highest specificity was in HA,LN and IV-C(96.9％).The serum levels of LN and IV-C were positively increasd with extrahepatic metastasis of PLC.Conclusion:The detetion of serum HA、LN and IV-C may be of value in diagnosing hepatic fibrosis and the serum L N and IV-C levels may be also as markers of PLC metastasis.关键词
肝纤维化/肝癌/透明质酸/IV型胶原Key words
Hepatic fibrosis/Primary liver cancer/Hyaluronic acid/Type IV collagen分类
医药卫生引用本文复制引用
邓芝云,张方信,于兰,高福兴,吕同德..血清透明质酸、层粘连蛋白及IV型胶原在肝纤维化
及肝癌中的变化分析[J].西北国防医学杂志,2001,22(1):60-62,3.
