南京医科大学学报（英文版）2005，Vol.19Issue(2)：60-62,3.
Monocyte chemoattractant protein-1 plays a key role in type 1 diabetes
Monocyte chemoattractant protein-1 plays a key role in type 1 diabetes
Dong Li 1Guoliang Liu2
作者信息
- 1. Department of Infectious Disease, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
- 2. Department of Endocrinology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
- 折叠
摘要
Abstract
Type 1 diabetes is an autoimmune disease resulting from the selective destruction of β cells in the pancreatic islets.In both human and rodent models of type 1 diabetes, the clinical disease is preceded by a progressive mononuclear cell invasion of the pancreatic islets (insulitis). In the early stage of insulitis, the major components are monocyte/macrophages, and the recruitment of mononuclear cells is a critical step in the pathogenesis of the type 1 diabetes. Studies have revealed that Monocyte chemoattractant protein-1(MCP-1)specifically recruits monocytes/macrophages into pancreas and plays an important role in the development of insulitis and diabetes.关键词
monocyte chemoattractant protein-1/insulits type 1 diabetesKey words
monocyte chemoattractant protein-1/insulits type 1 diabetes引用本文复制引用
Dong Li,Guoliang Liu..Monocyte chemoattractant protein-1 plays a key role in type 1 diabetes[J].南京医科大学学报（英文版）,2005,19(2):60-62,3.
