生殖医学杂志2006，Vol.15Issue(z1)：6-10,5.
Effects of IGF-Ⅱand TGF-β1 on invasiveness of placental trophoblast cells in patients with pregnancy-induced hypertension syndrome
Effects of IGF-Ⅱand TGF-β1 on invasiveness of placental trophoblast cells in patients with pregnancy-induced hypertension syndrome
Li Zhen 1Hu Yan 1Lin Gui-lan 1Wang Zhi 1Cheng Ya1
作者信息
- 1. Department of Obstetrics & Gynecology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
- 折叠
摘要
Abstract
Objective: This study was to investigate the invasiveness of pregnancy-induced hypertension (PIH) trophoblast cells and evaluate the effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion.Methods: Cytotrophoblast cells from normal and PIH placenta were separated and purified. Cytotrophoblast invasiveness of normal and PIH placenta was measured by in vitro invasion assay. Effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion were also studied.Results: In PIH group, cytotrophoblast invasiveness was dramatically decreased. In normal group, trophoblast invasiveness was significantly enhanced by IGF-Ⅱ but inhibited by TGF-β1. Neither IGF-Ⅱ nor TGF-β1 had statistically significant effects on PIH trophoblast invasion.Conclusions: PIH cytotrophoblast invasiveness dramatically decreases as compared to the normal level. IGF-Ⅱand TGF-β1 may play an important role in shallow trophoblast invasion on PIH.关键词
Insulin-like growth factor-Ⅱ/Transforming growth factor-beta/Trophoblasts/Invasion/Pregnancy-induced hypertension syndromeKey words
Insulin-like growth factor-Ⅱ/Transforming growth factor-beta/Trophoblasts/Invasion/Pregnancy-induced hypertension syndrome分类
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Li Zhen,Hu Yan,Lin Gui-lan,Wang Zhi,Cheng Ya..Effects of IGF-Ⅱand TGF-β1 on invasiveness of placental trophoblast cells in patients with pregnancy-induced hypertension syndrome[J].生殖医学杂志,2006,15(z1):6-10,5.
