中华医学杂志（英文版）2002，Vol.115Issue(4)：612-613,2.
导管介导基因转导心脏的对比研究
Comparative study of catheter-mediated gene transfer into heart
摘要
Abstract
Objective To investigate the feasibility and features of 3 catheter-mediated approaches of gene transfer into heart, including direct myocardial injection (DMI), coronary artery perfusion (CAP), and intrapericardial cavity injection (ICI). Methods Fifteen dogs were used, and 0.3ml (1×109 pfu) of an adenovirus (Adex1SR LacZ) was injected into the heart by 3 methods. The dogs were killed 5 days following injection, and gene expressions in heart and liver were evaluated by histochemical analysis. Conclusion Three catheter-mediated methods of gene transfer into the heart may be used and a reasonable approach should be chosen according to purpose.关键词
腺病毒/心肌/基因导入/心包/基因治疗Key words
adenovirus/myocardium/gene transfer/pericardial cavity/gene therapy分类
医药卫生引用本文复制引用
李建军,李庚山,黄从新,江洪,唐基柱,许家俐,夏豪,王晶..导管介导基因转导心脏的对比研究[J].中华医学杂志（英文版）,2002,115(4):612-613,2.基金项目
This project was supported by SRF for ROCS, SEM (No. 1998679). （No. 1998679）
