动物学研究2008，Vol.29Issue(6)：613-620,8.DOI:10.3724/SP.J.1141.2008.06613
吗啡和胆碱能拮抗剂联合给药对小鼠Y迷宫空间记忆提取及活动性的影响
Effect of Co-administration of Morphine and Cholinergic Antagonists on Y-maze Spatial Recognition Memory Retrieval and Locomotor Activity in Mice
摘要
Abstract
The interaction of morphine and cholinergic system was shown in previous studies. In the present study, we investigated whether morphine would interact with the cholinergic antagonists, scopolamine and atropine in a Y-maze spatial recognition memory. Pre-test treatments of morphine (5, 1.5, 0.5 mg/kg), scopolamine (1, 0.1 mg/kg), atropine (0.5, 0.1 mg/kg) were used in the experiments, relatively high or low doses were paired respectively as co-administration measures. The results showed that co-administration of morphine 0.5 mg/kg + scopolamine 0.1 mg/kg and morphine 0.5 mg/kg + atropine 0.1 mg/kg disturbed the inspective exploratory behavior (percent of arm duration) but not the inquisitive behavior (percent of arm visits) of the spatial memory retrieval, while the drugs didn't cause amnesia when single administered of the concerned low doses. Distinct interaction was found between scopolamine and morphine on increasing locomotor activity.关键词
记忆提取/吗啡/东莨菪碱/阿托品/Y迷宫Key words
Retrieval/Morphine/Scopolamine/Atropine/Y-maze分类
生物科学引用本文复制引用
何静,陈艳梅,王建红,马原野..吗啡和胆碱能拮抗剂联合给药对小鼠Y迷宫空间记忆提取及活动性的影响[J].动物学研究,2008,29(6):613-620,8.基金项目
国家自然科学基金(30770700 （）
30470553) National Natural Science Foundation of China (30770700 （）
30470553) （）
