天然产物研究与开发2008，Vol.20Issue(4)：614-616,638,4.
粗根荨麻水提取部分对佐剂性关节炎大鼠腹腔巨噬细胞分泌TNF-α及PGE2的影响
The Effects of Aqueous Fraction of Urtica macrorrhiza Hand-Mazz on Production of TNF-α, PGE2 Release from Peritoneal Macrophages Induced by LPS in Adjuvant Arthritis Rats
摘要
Abstract
To investigate the effects of aqueous fraction of Urtica macrorrhiza Hand-Mazz(Ur) on modulating tumor nec- rosis factor-alpha (TNF-α)and prostaglandin E2 (PGE2) production induced by lipopolysaceharide (LPS) in peritoneal macrophages in adjuvant arthritis rats and elucidate the possible mechanisms of anti-inflammatory and antirheumatoid effects of Ur, adjuvant arthritis (AA) rat was used as the model. The PMψ samples were taken at different time after medication. TNF-α, PGE2 levels were :measured by ELISA method. Production of TNF-α, and PGE2 increased in the cul-ture supematant of PMψ in AA model rats. Ur(400 and 200 mg/kg) could inhibit TNF-α and PGE2 release induced by LPS from PMψ in AA rats. The anti-inflaramatory mechanisms of Ur in AA rats might be reIated to its inhibitory effects on the level of TNF-α and PGE2 from PMψ in vivo.关键词
佐剂性关节炎/粗根荨麻/肿瘤坏死因子-α/前列腺素E2Key words
adjuvant arthritis/Urtica macrorrhiza Hand-Mazz/tumor necrosis factor-alpha/prostaglandin E2分类
医药卫生引用本文复制引用
李晓红,赵永娜,邵晓霞,李顺英,张荣平..粗根荨麻水提取部分对佐剂性关节炎大鼠腹腔巨噬细胞分泌TNF-α及PGE2的影响[J].天然产物研究与开发,2008,20(4):614-616,638,4.基金项目
This work was supported by Science and Technology Foundation of Yunnan Education Administration. （）
