癌症2001，Vol.20Issue(6)：620-623,4.
1364例恶性肿瘤p53蛋白表达的检测及其临床病理学意义
Immunohistochemical Detection of p53 Protein Alterated Expression in 1 364 Patients with Maligant Tumors and Its Clinicopathological Significance
卢晓梅 1陈朝伦 2沈宝茵2
作者信息
- 1. 新疆医科大学一附院包虫病研究所 ,
- 2. 新疆医科大学一附院病理科 ,
- 折叠
摘要
Abstract
Objective：The aim of this study was to investigate the effect of p53 gene alterated expression on human carcinogenesis. Methods： p53 protein expression in 1 364 patients with malignant tumors and 628 benign lesions was detected by immunohistochemistry (LSAB). Results： The frenquency of p53 protein positive was significant higher in malignant tumors [56.67％ (733/1364)] than those in related benign lesions [6.7％ (42/623) (P< 0.001)]; It was revealed the similar situation as compared squamous cell cancer (615), adenocarcinoma (382), and other types of malignancies (367) with their related benign lesions respectively (P< 0.001). Conclusion： Alterated expression of p53 protein (gene multation or protein accumulation) may involve one of the critical events of human carcinogenesis. Detection of p53 overexpression may be a useful biomarkers for assessment of maligant tumors.关键词
肿瘤/p53基因异常/免疫组化分类
医药卫生引用本文复制引用
卢晓梅,陈朝伦,沈宝茵..1364例恶性肿瘤p53蛋白表达的检测及其临床病理学意义[J].癌症,2001,20(6):620-623,4.
