中国临床康复2004，Vol.8Issue(28)：6248-6250,3.
脑梗死患者神经功能缺损程度评估中 S-100b蛋白及神经元特异性烯醇化酶的作用
Effect of S100b and neuron-specific enolase on the quantitative assessment of neurologic impairment in patients with cerebral infarction
佘正明 1李云 2吕天河 3李作汉4
作者信息
- 1. 吴江市第一人民医院神经科,江苏省吴江市,215200
- 2. 洪泽县人民医院神经科,江苏省洪泽县,223100
- 3. 淮安市第一人民医院放免中心,江苏省淮安市,223001
- 4. 南京医科大学脑血管病研究所,江苏省南京市,210004
- 折叠
摘要
Abstract
BACKGROUND:S-1oob and neuron-specific enolase(NSE) can be used as chemical markers of neuron damage.However,it is not clear to which extent S-100b and NSE can predict ischemic neuron damage and neurologic impairment. OBJECTIVE:To investigate to which extent S-100b and NSE can predict ischemic neuron damage and neurologic impairment, and the relationship between hyperglycemia and neuron damage. DESIGN:Diagnosis based non-randomized control study. SETTING and PARTICIPANTS:The study was conducted in the People's Hospital of Hongze County during the March 2002 and March 2003.Forty-three patients with cerebral infarction aged 52-83 years(23 males and 20 females) and 33 health control subjects aged 48-80 years(19 males and 14 females) entered the study. INTERVENTIONS:Serum level of S-100b and NSE was measured by Enzyme-Linked Immunosorbent Assay.The cerebral infarction area was measured by using CT.NIHSS was used to assess the neurologic impairment.MAIN OUTCOME MEASURES:① serum level of S-100b and NSE yb bith groups.② Correlations between the level of S-100b and NSE and the area of cerebral infarction. RESULTS:At all time points of examination, serum level of S-100b and NSE was always higher in the infarction group than that in the control group. The level of S-100b and NSE was elevated from 24 hours post infarction onwards, at a level(1.64± 0.41) μ g/L and(8.54± 2.37) μ g/L.The peak value[(2.15± 0.42) μ g/L,(11.36± 3.14) μ g/L] was achieved at the third day post-infarction .The levels of S-1oob and NSE did not return to normal until 7 days post-infarction[(1.74± 0.38),(9.13± 2.58) μ g/L]. It showed a positive association between the level of S-100b and the area of cerebral infarction and between the level of S-100b and the severity of clinical presentations at day 3(r=0.64,0.49,P< 0.001,P< 0.002).There was a positive correlation between the level of NSE and the area of cerebral infarction.(r=0.39,P< 0.05) while there was no significant correlation between NSE level and the severity of clinical presentations(r=0.15,P >0.05).The level of S100b and NSE was significantly higher in the cerebral infarction with hyperglycemia than that in the group of patients with cerebral infarction with normal glycemia. CONCLUSION:Serum level of S-100b and NSE are sensitve chemical markers for predicting the extent of ischemic neuron damage and loss of neural function.Hyperglycemia can result in a more severe ischemic cerebral injury.关键词
脑梗塞/磷酸丙酮酸水合酶/血糖分类
医药卫生引用本文复制引用
佘正明,李云,吕天河,李作汉..脑梗死患者神经功能缺损程度评估中 S-100b蛋白及神经元特异性烯醇化酶的作用[J].中国临床康复,2004,8(28):6248-6250,3.
