西南国防医药2008，Vol.18Issue(5)：625-631,7.
从青阳参提取的带7个糖残基的新C21甾体苷
C21 steroidal glycosides with seven sugar residues extracted from Cynanchum otophyllum Schneid
摘要
Abstract
Objective:To investigate the structures of compounds in Qingyangshen tablets.Methods:The acetic ether extracts from the rhizome of Cynanchum otophyllum Schneid(Asclepiadaceae)was isolated by column chromatography,and the structures of the purified compounds were determined by spectral method.Results:Two new C21-steroidal glycosides were isolated shose structures were determined as caudatin 3-O-α-L-cymaropyranosyl-(1→4)-α-D-oleandropyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-diginopyranoside(1),and caudatin 3-O-β-D-cymaropyranosyl-(1→4)-α-D-oleandropyranosyl-(1→4)-α-L-cymaropyranosyl-α-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-diginopyranoside(2),respectively.Conclusion:C21 steroidal glycosides 1 and 2 in Qingyangshen tablets are composed of a C21 steroidal aglycone moiety of the 3-OH substitution and a sugar chain.This chain consists of seven sugar residues which are 2-deoxy-hexose and glucose.All linkages between them are 1→4.关键词
青阳参/C21甾体苷/萝藦科/癫痫/迁慢性肝炎Key words
Cynanchum otophyllum Schneid/C21 steroidal glycosides/Asclepiadaccae/epilepsy/chronic hepatitis分类
医药卫生引用本文复制引用
赵益斌,任虹燕,张培华,左国营,张青,徐贵丽..从青阳参提取的带7个糖残基的新C21甾体苷[J].西南国防医药,2008,18(5):625-631,7.基金项目
国家自然科学基金资助项目(30572322)和云南省自然科学基金资助项目(2005C0036Q) （30572322）
