物理化学学报2008，Vol.24Issue(4)：625-632,8.
Triton X-100对血红蛋白/利巴韦林/H2O体系中血红蛋白性质和药物释放的影响
Effects of Triton X-100 on Properties of Hemoglobin and Controlled Release of Drug in Hemoglobin/Ribavirin/H2O System
摘要
Abstract
Effects of Triton X-100 on the properties of hemoglobin (Hb) and on the controlled release of dbavirin were studied using the methods of UV-Vis spectrum, fluorescence spectrum, zeta potential, conductivity, high-performance liquid chromatographic (HPLC), and image morphology in Hb/ribavirin/H2O system. With the increase of concentration of Triton X-100 in the system, the intrinsic fluorescence intensity, synchronous fluorescence intensity, fluorescence polarization, zeta potential, and morphology of Hb all changed gradually, and the ribavirin located on the Hb surface interaction of Triton X-100 with Hb was predominant. Hb was unfolded and denaturized. A little Triton X-100 can protect Hb from the effects of ribavirin.关键词
血红蛋白/性质/利巴韦林/控制释放/TritonX-100Key words
Hemoglobin/ Property/ Ribavirin/ Controlled release/ Triton X-100分类
化学化工引用本文复制引用
刘天晴..Triton X-100对血红蛋白/利巴韦林/H2O体系中血红蛋白性质和药物释放的影响[J].物理化学学报,2008,24(4):625-632,8.基金项目
国家自然科学基金(20573091)资助项目 （20573091）
