中华医学杂志（英文版）2003，Vol.116Issue(1)：62-65,4.
A combination of Ang Ⅱ and carbon tetrachloride accelerates process of hepatic fibrosis
A combination of Ang Ⅱ and carbon tetrachloride accelerates process of hepatic fibrosis
周馨 1李定国 1李宣海 2陆汉明 1张文竹3
作者信息
- 1. Department of Gastroenterology and Hepatology, Xin Hua Hospital, Shanghai Second Medical University, Shanghai 200092, China
- 2. Shanghai Second Medical University, Shanghai 200025, China
- 3. Department of Pathology, Xin Hua Hospital, Shanghai Second Medical University, Shanghai 200092, China
- 折叠
摘要
Abstract
Objective To assess whether Angiotensin Ⅱ (Ang Ⅱ) and carbon tetrachloride (CCl4) used in combination could accelerate the process of fibrosis and whether Ang Ⅱ play a role in exaggerating hepatic fibrosis in rats.Methods Ang Ⅱ was injected into the abdominal cavity of Sprague-Dawley (SD) rats together with subcutaneous injection of CCl4. Rats were killed after 14 and 28 d. Blood serum and liver specimen were collected. The extent of fibrosis in the stained liver tissue sections was determined with the KS 400 Image Analysis System. Results Rats receiving Ang Ⅱ and CCl4 for 28 d showed extensive liver fibrosis. Along with the increase of hepatic fibrosis, the serum concentration of Ang Ⅱ went up gradually. Conclusions A combination of Ang Ⅱ and CCl4 would accelerate the process of hepatic fibrosis. Ang Ⅱ probably took part in the occurrence of heparic fibrosis.关键词
fibrosis/angiotensin Ⅱ/carbon tetrachlorideKey words
fibrosis/angiotensin Ⅱ/carbon tetrachloride分类
医药卫生引用本文复制引用
周馨,李定国,李宣海,陆汉明,张文竹..A combination of Ang Ⅱ and carbon tetrachloride accelerates process of hepatic fibrosis[J].中华医学杂志（英文版）,2003,116(1):62-65,4.
