兰州大学学报（医学版）2007，Vol.33Issue(3)：62-67,6.
阿司匹林对卡托普利引起的咳嗽的逆转作用
Effects of aspirin on captopril-related cough
摘要
Abstract
Objective To investigate the relationships between captopril CT-related cough and thromboxane B2 (TXB2) as well as F1α(6-Keto-PGF1α) and to confirm whether adding aspirin or substituting losartan (LS) to CT can alleviate CT-related cough or not. Methods Five hundred and ninety-eight cases suffered from cardiovascular diseases were divided into CT group and LS group. The symptoms and incidence of the cough were evaluated. LS was used to replace CT in 28 patients with CT-induced cough and aspirin was given to other 28 patients with cough. Contents of TXB2 and 6-Keto-PGF1α in plasma and urine were detected by radioimmunoassay. Results (1) The incidence of the cough was 18.67% in CT group while 1.68% in LS group (P ＜0.01). Twenty-seven out of 28 patients with CT-induced cough stopped coughing as CT was replaced by LS. When additional aspirin treatment was used among patients with CT-induced cough, 21.43% were cured and 25% were found with diminished symptoms. There was no correlation between the severity of cough and the dosage of CT (＞0.05); (2) Compared with patients without cough, patients with CT-related cough revealed decreased plasma concentration of TXB2 and increased plasma and urine concentrations of 6-Keto-PGF1α, and higher ratio of TXB2/6-Keto-PGF1α (all P ＜0.05); (3) The ratio of TXB2/6-Keto-PGF1α in plasma or urine was reduced when CT was replaced with LS in patients with CT-related cough (P ＜0.05 or ＜0.01). When aspirin was used to CT-treated patients with cough, the ratio of TXB2/6-Keto-PGF1α in plasma or urine was decreased (P ＜0.05 or＜0.01). Conclusions The imbalance of TXB2 and 6-Keto-PGF1α is one of the causes for angiotensin converting enzyme inhibitor (ACE-Ⅰ) related cough. Patients with CT-related cough may be cured with LS. Treatment of CT with additional aspirin may extend the range of CT applications, which can decrease its cost and improve therapeutic effects.关键词
卡托普利/咳嗽/阿斯匹林/氯沙坦Key words
captopril/ losartan/ cough/ aspirin分类
医药卫生引用本文复制引用
余静,赵锋,郭雪娅,阎炜,李秀丽,常鹏,张缤..阿司匹林对卡托普利引起的咳嗽的逆转作用[J].兰州大学学报（医学版）,2007,33(3):62-67,6.基金项目
Supported by Tackling-key-problems Project in Science and Technology of Gansu Province(GS002-A43-053). （GS002-A43-053）
