体外循环患者血浆致炎因子、抗炎因子、内毒素的变化及其临床意义OACSTPCD
Changes of inflammatory and anti-inflammatory cytokine levels in serum and its significance in patients with cardioipulmonary bypass
目的观察体外循环心脏手术患者血浆致炎因子(肿瘤坏死因子,白介素6)、抗炎因子(白介素4,白介素10)及内毒素的变化.探讨致炎因子与抗炎因子在体外循环炎症反应中的作用.方法采用鲎试剂,ELISA等技术分别观察体外循环和未进行体外循环的患者血浆内毒素、TNF-α、IL-6、IL-4、IL-10的水平.结果体外循环时发生内毒素血症;体外循环时血浆TNF-α、IL-6、IL-4、IL-10水平显著升高,但抗炎因子IL-4,1L-10释放迟于致炎因子TNF…查看全部>>
Objective:To explore the changes of plasma inflammatory cytokine, anti - inflammatory cytokine and endotoxin levels in patients with Cardiopulmonary bypass, and further more, to analyse their roles in the development of systemic inflammation response. Methods: Sixteen patients with rheumatic heart disease(8 cases with cardiopulmonary bypass,8 case without cardiopulmonary bypass)were selected for this study. Limulus amebocyte lysate chromogenic assay and ELIS…查看全部>>
王改非;法宪恩
河南平顶山市第一人民医院胸心外科,467000郑州大学第二附属医院心血管外科,450051
医药卫生
体外循环全身炎症反应肿瘤坏死因子白介素
Cardiopulmonary bypassSystemic inflammation responseTumor necrosis factor- αInterleukin
《中国现代医学杂志》 2003 (23)
63-65,69,4
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