脑溢安对脑出血大鼠脑内p38MAPK信号转导通路的影响OA北大核心CSTPCD
Effects of Nao Yi-an on p38 MAPK signal transduction pathway in experimental intracerebral hemorrhagic brain of rats
目的研究脑溢安对脑出血大鼠脑内p38丝裂原活化蛋白激酶(Mitogen-activated protein kinase,p38MAPK)信号转导通路的影响,探讨中药脑溢安颗粒(简称脑溢安)对脑出血的保护作用机制.方法采用胶原酶注射建立大鼠脑出血模型,应用免疫共沉淀、激酶反应及Western blot技术检测脑出血大鼠脑内p38MApK活性变化及脑溢安对p38MAPK活性的影响.结果脑出血损伤后1 h p38MAPK活性增强,出血损伤后6 h达高…查看全部>>
Objective: To investigate the effect of the traditional Chinese medicine complex Nao Yi-an granule (NYA) on p38MAPK signal transduction pathway in the intracerebral hemorrhagic (ICH) brain of rats and explore the protective mechanisms of NYA on ICH. Methods: ICH rat models were established by stereo-taxically injecting 0.4 U type Ⅶ collagenase into the right globus pallidus(GP).The p38MAPK activity was an-alyzed by immunoprecipitation, kinase assay and Weste…查看全部>>
肖岚;黎杏群;张花先
中南大学湘雅医院,中西医结合科,湖南,长沙,410008中南大学湘雅医院,中西医结合科,湖南,长沙,410008中南大学湘雅医院,中西医结合科,湖南,长沙,410008
医药卫生
脑出血p38MAPK脑溢安颗粒大鼠
intracerebral hemorrhagep38MAPKChinese meteria medicarats
《中国现代医学杂志》 2004 (10)
63-65,71,4
Suported by National Science Fund (NO. 30171192)
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