中国医科大学学报2001，Vol.30Issue(1)：64-65,68,3.
p16、p15蛋白在小儿急性淋巴细胞白血病的表达及临床相关性研究
Expression of p16 and p15 Proteins in Acute Lymphoblastic Leukemia of Children
胡宛如 1张瑞英 1郭承吉 1王立娥 2都姝妍2
作者信息
- 1. 中国医科大学第一临床学院儿科,
- 2. 第一临床学院中心实验室
- 折叠
摘要
Abstract
Objective:Our aim was to To clarify the roles of p16 and p15 proteins in the genesis of acute lymphoblastic leukemia(ALL).Methods:Twenty-three samples of ALL were studied by the method of indirect immunofluorescence.Flow cytometer was used to estimate the cellular fluorescent intensity to determine the levels of p16 and p15 proteins.Results:Negative expression for p16 protein was found in 10 of 23 samples,and 8 of 23 were p15 negative expression.Both kinds of proteins were abscent in 6 samples.2 of 3 cases of T-ALL were negative expression of p16,p15 protein.In non T-ALL,6 of 13 were negative expression for p16 protein,5 of 13 were p15 protein deficient.The expression rates of p16,p15 protein in high leukocyte group were lower than those of non-high leukocyte group(P<0.05).The expression rates of p16,p15 proteins in HR-ALL were lower than those of SR-ALL(P<0.05).Conclusion:The p16 and p15 proteins take part in the genesis of ALL.Negative expression of p16,p15 proteins might imply the poor clinical outcome.关键词
p16蛋白/p15蛋白/急性淋巴细胞白血病/流式细胞仪分类
医药卫生引用本文复制引用
胡宛如,张瑞英,郭承吉,王立娥,都姝妍..p16、p15蛋白在小儿急性淋巴细胞白血病的表达及临床相关性研究[J].中国医科大学学报,2001,30(1):64-65,68,3.
