中国动脉硬化杂志2001，Vol.9Issue(1)：64-66,3.
血浆降钙素基因相关肽与冠心病患者冠状动脉病变严重程度及左心室功能的关系
The Relationships between Plasma Clcitonin Gene Related Peptide and the Severity of Coronary Lesions as well as Left Ventricular Function in Patients with Coronary Heart Disease
罗初凡 1杜志民 1胡承恒 1李怡 1伍贵富1
作者信息
- 1. 中山医科大学附属第一医院心内科，广东省广州市 510080
- 折叠
摘要
Abstract
Aim To investigate the relationships between plasma calcitoningenerelated peptide (CGRP) and the severity of coronary lesions and left ventricular function in patients with coronary heart disease. Methods In 42 patients with fixed stenosis coronary artery ≥70% of luminal diameter in the major coronary arteries and 15 normal persons, the concentration of plasma CGRP was measured using radioimmunoassay (RIA). The relationships between plasma CGRP and the Leaman coronary artery score as well as left ventricular ejection fraction (LVEF) were assessed. Results The concentration of plasma CGRP was obviously lower in the coronary disease group than in the control group (276.12±164.75 ng/L vs 411.44±110.32 ng/L, P<0.01). The concentration of plasma CGRP was negatively related to the Leaman score (r=－0.61, P<0.001) and positively to LVEF (r=0.57, P<0.001). The Leaman score had no significant correlation to LVEF in the whole group. However, in the subgroup with the level of plasma CGRP <250 ng/L, the Leaman score had significantly negative correlation to LVEF (r=－0.49, P<0.05). Conclusions The plasma CGRP had correlation to both the severity of coronary lesions and left ventricular function in patients with coronary heart disease. In the patients with decreased concentration of plasma CGRP, the left ventricular function deteriorated with the progress of coronary lesions.关键词
降钙素基因相关肽/冠状动脉疾病/心室功能,左/冠状动脉造影/放射免疫分析分类
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罗初凡,杜志民,胡承恒,李怡,伍贵富..血浆降钙素基因相关肽与冠心病患者冠状动脉病变严重程度及左心室功能的关系[J].中国动脉硬化杂志,2001,9(1):64-66,3.
