中国现代医学杂志2005，Vol.15Issue(5)：649-653,5.
多奈哌齐治疗轻中度阿尔茨海默病患者的临床研究
Clinical study of donepezil in treatment of patients with mild to moderate Alzheimer's disease
杜小平 1张宏根 2杨期东 1高成忠2
作者信息
- 1. 中南大学湘雅医院,神经内科,湖南,长沙,410008
- 2. 湖南省脑科医院,湖南,长沙,410007
- 折叠
摘要
Abstract
[Objective] To study the efficacy and safety of donepezil in the treatment of patients with mild tomoderate Alzheimer's disease (AD) in our country. Methods: 48 cases with mild to moderate AD were divided intotwo groups randomly and treated bydonepezil and rivastigmine, respectively. Mini Mental State Examination (MMSE),Blessed-Routh Rating Scale BRRS) and Global Deterioration Scale (GDS) were evaluated for efficacy, Vital signs,ECG and laboratorial tests were measured every 4 weeks for safety. Results: The scores of MMSE, GDS and BRRSin the two groups were improved greatly (P＜0.05). But the difference of those scores between two groups at bothbaseline and end-point was not ignificant P＞5). Gastrointestinal reaction as adverse event occurred in 13.6%～29.5% patients in two groups and more commonly in rivastigmine treatment. Conclusion: Donepezil and rivastigmineboth similarly improve cognitive ability, dementia degree and daily living ability in AD patients in our country andhave generally well toleration and safety.关键词
多奈哌齐/卡巴拉汀/阿尔茨海默病/胆碱酯酶抑制剂Key words
donepezil/rivastigmine/Azehmer's disease/cholinesterase inhibitors分类
医药卫生引用本文复制引用
杜小平,张宏根,杨期东,高成忠..多奈哌齐治疗轻中度阿尔茨海默病患者的临床研究[J].中国现代医学杂志,2005,15(5):649-653,5.
