癌症2001，Vol.20Issue(6)：651-653,3.
鼻咽癌患者放疗后张口困难及其影响因素
Radiation Induced Temporomandibular Joint Lesion in Patients with Nasopharyngeal Carcinoma
陈明 1曾祥发 1赵充 1吴少雄 1黄晓延 1韩非 1罗伟 1卢泰祥 1崔念基1
作者信息
摘要
Abstract
Objective：The aim of this study was to evaluate radiation induced temporomandibular joint damage in the patients with nasopharyngeal carcinoma, and its correlative factors were analyzed. Methods： From November 7, 1966 to July 2, 1999, 352 patients with nasopharyngeal carcinoma received radical conventional radiotherapy were eligible for this analysis. The total dose of the temporomandibular joint were 51.90－ 78.89 gray and the overall treatment time were 35－ 141 days. The endpoint was the distance between two dens incisivus medialis (DDIM). The relationship between total doses and temporomandibular joint lesion was illustrated with curve estimation. Multivariate analysis with Logistic Regress was performed to evaluate the significance of prognostic variables on temporomandibular joint lesion. Results： The patient of DDIM60.00－ 70.00 gray, and >70.00－ 78.89 gray were 46.4％ , 53.5％ , and 62.3％ , respectively (P=0.050); and in the patients who insisted in opening mouths practice or not were 51.6％ and 61.7％ respectively (P=0.028); and in patients at age of 18－ 42 and 43－ 71 were 54.1％ and 62.7％ respectively(P=0.040). They were all significant prognostic factors for radiation induced temporomandibular joint lesion. Conclusion： Radiation induced temporomandibular joint lesion in radiation treated NPC patients was serious. The total dose of temporomandibular joint, opening mouths practice and age are three significant prognostic factors.关键词
鼻咽肿瘤/放射疗法/颞颌关节/放射损伤分类
医药卫生引用本文复制引用
陈明,曾祥发,赵充,吴少雄,黄晓延,韩非,罗伟,卢泰祥,崔念基..鼻咽癌患者放疗后张口困难及其影响因素[J].癌症,2001,20(6):651-653,3.
