中国临床康复2004，Vol.8Issue(29)：6536-6537,2.
乳腺癌易感蛋白2的结构和功能
Structure and function of breast cancer susceptibility protein 2
卢向阳 1田云 1周海燕 1彭丽莎 1徐锋1
作者信息
- 1. 湖南农业大学生化与发酵工程实验室,湖南省长沙市,410128
- 折叠
摘要
Abstract
BACKGROUND: Breast cancer susceptibility protein BRCA 2 encoded by BRCA2 gene is a tumor suppressor required for maintenance of chromosomal stability in mammalian cells and playing a pivotal role in biological response to DNA damage. Many researches showed that BRCA2 protein was closely related to the pathogenesis of hereditary breast cancer, ovarian cancer and Fanconi anemia (FA), presumably involving DNA double-stranded break (DSB) repair, but the exact mechanism of its actions remains unknown.OBJECTIVE: To review the researches on BRCA2 protein structure and DNA repair so as to elucidate the mechanism of BRCA2 in DNA repair.STUDY SELECTION: The documents about BRCA2 protein and DNA repair were chosen.DATA SOURCES: The data were searched overall including electronic search, craft search and personal communication search and so on. DATA EXTRATION: The information about BRCA2 protein and DNA repair in the researched documents was surveyed.MAIN OUTCOME MEASURES: The structure, function model and mechanism of BRCA2 protein in DNA repair are explored.RESULTS: The results showed that BRCA2 protein performed important functions in tumor suppression. The DNA) binding activities of DNA-binding domain(DBD) of BRCA2, in conjunction with the RAD51-binding activities of the BRC repeat, were directly associated with DSB repair during homologous recombination.CONCLUSION: BRCA2 protein plays an important role in DSB repair, but the exact process and signal transduction pathway still need further study.The study of BRCA2 may hold significant value in developing new treatment target for diseases involving DNA damage.关键词
乳腺肿瘤/基因,抑制,肿瘤/DNA修复/重组,遗传分类
医药卫生引用本文复制引用
卢向阳,田云,周海燕,彭丽莎,徐锋..乳腺癌易感蛋白2的结构和功能[J].中国临床康复,2004,8(29):6536-6537,2.
