中华医学杂志（英文版）2002，Vol.115Issue(5)：654-657,4.
国人2号染色体一区段与原发性高血压的连锁分析研究
Linkage analysis of a region on chromosome 2 with essential hypertension in Ch inese families
摘要
Abstract
Objective To verify the linkage of the candidate regions identified in a previous study (m arkers D2S168, D2S151, D2S142 on chromosome 2) with hypertension in Chinese fami lies.Methods A genetic linkage study focused on chromosome 2 was performed on 240 Chinese fam ilies containing 856 patients with essential hypertension. A total of 1080 indi viduals were genotyped using 9 highly polymorphic microsatellite markers around the candidate regions on chromosome 2 with an average spacing of 5cM. Non-pa rametric linkage (NPL), parametric linkage analysis and transmission-disequilib rium test (TDT) with the GENEHUNTER software were used to assess evidence for li nkage.Results Linkage of a region on chromosome 2 around D2S151 and D2S142 with hypertension w as confirmed by different statistical methods (NPL, LOD score and TDT). However , the linkage of D2S168 could not be replicated in this extension study.Conclusions The data suggest that a region on chromosome 2 at or near the loci of D2S142 and D2S151 may harbor genes responsible for the development of essential hypertensi on in Chinese.关键词
高血压/基因/连锁分析Key words
hypertension/gene/linkage analysis分类
医药卫生引用本文复制引用
朱鼎良,黄薇,王厚义,熊墨淼,初少莉,金力,王谷亮,何鑫,袁文涛,钱岳晟,赵光胜..国人2号染色体一区段与原发性高血压的连锁分析研究[J].中华医学杂志（英文版）,2002,115(5):654-657,4.基金项目
This study was supported by grants of "Chinese High Tech Program (863)" (102-1 0-02-03, Z19-01-03-01A) and "National Key Program on Basic Research (973)" (G19980510) from the Ministry of Science and Technology, China. （863）
