中华医学杂志（英文版）2002，Vol.115Issue(1)：65-68,4.
Hepatic microcirculatory disturbances in patients with chronic hepatitis B
Hepatic microcirculatory disturbances in patients with chronic hepatitis B
摘要
Abstract
Objective To document morphological changes in hepatic microcirculation in liver tissue with hepatitis B and the pathogenesis of hepatic microcirculatory disturbances. Methods Liver tissue samples were obtained from patients with hepatitis B by liver biopsy. These samples were examined with a light microscope and transmission electron microscope. Results Hepatic microcirculatory disturbances existed in patients with hepatitis B, including those with normal liver function, manifested by red blood cell aggregation in sinusoids seen under light microscope and sinusoidal capillarization seen under electron microscope. Weibel-Palade bodies in sinusoidal endothelial cells were seen in 26 out of 53 cases. Intimate contacts were found between lymphocyte/Kupffer cells and sinusoidal endothelial cells. Conclusions Hepatic microcirculatory disturbances exist in patients with hepatitis B .The appearance of Weibel-Palade bodies in sinusoidal endothelial cells may be a key step in the development of hepatic microcirculatory disturbances.关键词
liver/microcirculation/chronic hepatitis B/Weibel-Palade bodyKey words
liver/microcirculation/chronic hepatitis B/Weibel-Palade body分类
医药卫生引用本文复制引用
郝菁华,石军,任万华,韩国庆,朱菊人,王书运,谢英渤..Hepatic microcirculatory disturbances in patients with chronic hepatitis B[J].中华医学杂志（英文版）,2002,115(1):65-68,4.基金项目
This study was supported by Shandong Science and Technology Committee (No. 981216511). （No. 981216511）
