中国临床康复2003，Vol.7Issue(4)：670-671,2.
肢体高能量火器伤后脑病理生理变化机制
Pathophysiological changes and mechanism of cerebral pathological after high-energy wound in extremities of dogs
封亚平 1章翔 1费舟 1吴景文 1武弋 1梁景文 1王西玲1
作者信息
- 1. Institute of Neurosurgery of Chinese PLA, Xijing Hospital,Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China
- 折叠
摘要
Abstract
AIM: To study the mechanism of cerebral pathological and pathophysiological changes after extremity gunshot wounds at molecular level. METHODS: M-193, 5.56 mm bullets were used to shoot the most plentiful part of the hind extremities of the dogs. C-fos gene expression in neurons of cerebral tissues of different time intervals after gunshot in the subject and control groups were detected with immunohistochemistry. RESULTS: No C-fos gene expression was detected in the cerebral cortical neurons in the control group. But in the subject group, C-fos expression increased in the cerebral neurons 30 min after injury, reached the peak 6 houre(P＜0.05), and began to decrease 10 hours post-injury. CONCLUSION: After extremity gunshot wound C-fos expression in neurons of distal parts is the early response of the body to the injury, which might be caused by Leao' s spreading depression(SD), and correlated to extracellular transduction and cell apoptosis.关键词
pathology, surgical/brain injuries/wounds and injuriesKey words
pathology, surgical/brain injuries/wounds and injuries分类
医药卫生引用本文复制引用
封亚平,章翔,费舟,吴景文,武弋,梁景文,王西玲..肢体高能量火器伤后脑病理生理变化机制[J].中国临床康复,2003,7(4):670-671,2.
