中国现代医学杂志2008，Vol.18Issue(6)：673-678,6.
应用相干光断层扫描成像术测定正常国人视网膜神经纤维层厚度及影响因素分析
Measurement and variation of thickness of retinal nerve fiber layer in normal Chinese people by optical coherence tomography
李晓宇 1潘英姿 1晏晓明 1李梅 1乔荣华 1才瑜 1王捷 1刘丽娜1
作者信息
- 1. 北京大学第一医院,眼科,北京,100034
- 折叠
摘要
Abstract
Abstract:[Objective] To measure the thickness of peripapillary retinal nerve fiber layer(RNFL) in normal Chinese subjects with optical coherence tomography(OCT) and to identify the factors that might affect RNFL thickness.[Methods]Total of 202 randomly selected normal eyes from 202 subjects of both genders with different age(8～74 years) and refraction error(-8.00 to +4.00 D)underwent Stratus OCT 4.0 examination.RNFL thickness in four quadrants,twelve clock-hours and average RNFL thickness were determined.Meanwhile,the effects of age,refraetion,gender and disc area on average RNFL thickness were statistically investigated with multiple linear regression analysis.Also,comparison of average RNFL thickness among different age and refraction groups was statistically estimated by One-way AVON analysis.[Results] ① Average RNFL thickness was(108.63±9.70)μm.RNFL was thickest in the inferior quadrimt[(139.17±15.79)μm],followed by superior[(134.61±17.80) μm],temporal[(85.37±21.25)μm] and nasal[(75.19±17.06)μm]quadrants.②Average RNFL thickness decreased with age and inereasing myopia;gender and optic disc area had no effect On it.The multiple linear regression equation was:y=-0.262 x1+1.588 x2+ 121.690(P1=0.000,P2=0.000;y=average RNFL thickness,x1=age,x2=refraction). Meanwhile,average RNFL became signitleantly thinner either for people older than 50 or for high myopic eyes.[Conclusions] RNFL thickness measurement in normal Chinese population was estimated;average RNFL thickness was mainly affected by age and refraction;Our results proved the importance and impendence of building a RNFL normative database based on Chinese population and adjusted by possibly affecting factors (age,refraction and so on)to aid the evaluation and monitor of glaucoma in China.关键词
相干光断层扫描仪/视网膜神经纤维层/正常人Key words
optical coherence tomography(OCT)/ retinal nerve fiber layer(RNFL)/normal eyes分类
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李晓宇,潘英姿,晏晓明,李梅,乔荣华,才瑜,王捷,刘丽娜..应用相干光断层扫描成像术测定正常国人视网膜神经纤维层厚度及影响因素分析[J].中国现代医学杂志,2008,18(6):673-678,6.
