中国临床康复2004，Vol.8Issue(30)：6764-6765,2.
蒙古族人群血管紧张素转换酶基因多态性与高血压的关系
Association between angiotensin-converting enzyme gene polymorphism and hypertension in Mongolian population
摘要
Abstract
BACKGROUND: Studies on the relationship between angiotensin-converting enzyme(ACE) and hypertension is well documented, but so far the relationship remains poorly understood in Mongolian population, a minority group at greater risk for hypertension.OBJECTIVE: To explore the association between ACE gene polymorphism and hypertension in Mongolian population.DESIGN: A cross-sectional study was conducted.SETTING and PARTICIPANTS: This study was conducted in the inhabitants who lived in Kezuohouqi in Tongliao City, Inner Mongolia of China. Fifty-one hypertensives and 32 normotensives, both positive for a family history of hypertension, along with another 64 hypertensives and 85 normotensives without family history of hypertension, were enrolled in this study.INTERVENTIONS: Polymerase chain reaction technique was used to detect the insertion/deletion(I/D) polymorphism of ACE gene.MAIN OUTCOME MEASURES: The frequency of ACE I/D polymorphism genotypes and allele was compared.RESULTS: There was no significant difference in the frequency of ACE genotypes(Ⅱ, ID, DD) among these 4 groups(P＞0.1). The frequency of ID genotype was the highest, followed by II genotype and then by DD genotype. The frequencies of I and D alleles were not significantly different among these 4 groups(P＞0.01), but the frequency of I allele appeared higher.CONCLUSION: The I/D polymorphism of ACE gene is not related to hypertension in Mongolian population.关键词
肽基二肽酶A/多态现象(遗传学)/高血压分类
医药卫生引用本文复制引用
刘丽娟,叶宏,佟伟军,冯华,黄桂蓉,李永山,巴图,张永红..蒙古族人群血管紧张素转换酶基因多态性与高血压的关系[J].中国临床康复,2004,8(30):6764-6765,2.基金项目
国家自然科学基金资助项目(30040040) （30040040）
