中风与神经疾病杂志2001，Vol.18Issue(2)：67-69,3.
阿耳茨海默性痴呆与血管性痴呆的
ApoE基因多态性研究
A study on ApoE genotype in Alzheimer-type dementia and vascular dementia
贾建平 1张津 1张新卿 1闵宝权 1周卫东 1董会卿 1杨静芳 1董秀敏1
作者信息
摘要
Abstract
Objective To explore the frequency of ApoE genotype in Alzheimer-type dementia (AD) and vascular dementia (VD), to find Chinese features of these genotype in comparison with western reports，to evaluate the role of ApoE genotype examination in predicting diagnosis, and to compare the difference in ApoE genotype in AD and VD. Methods Using PCR-RFLP technique to examine ApoE genotype in 41 cases with AD, 35 cases with VD and 30 control. Results There was a higher ε4 allelic gene frequency (P<0.05) in AD than in VD and control in the groups of < 70 year old （P＜0.01 and P＜0.05）. However, a lower ε4 allelic gene frequency (P<0.01) in AD than in VD and control in the groups of 70 year old. Conclusion (1)This study indicates that there is a correlation between ApoE allelic gene ε4 and sporadic AD. The genotype is mainly 4/3, in which ε4/4 is lower than report in foreign countries. (2) The frequency of ApoE ε4 genotype is higher in AD than in VD group (P<0.05). (3) When evaluating the correlation between ApoE ε4 and AD, the factor of age should be emphasized. The carrier of ε4 with age of <70-year-old is vulnerable to AD.
关键词
阿耳茨海默性痴呆/血管性痴呆/ApoE基因多态性分类
医药卫生引用本文复制引用
贾建平,张津,张新卿,闵宝权,周卫东,董会卿,杨静芳,董秀敏..阿耳茨海默性痴呆与血管性痴呆的
ApoE基因多态性研究[J].中风与神经疾病杂志,2001,18(2):67-69,3.
