洛阳工学院学报2000，Vol.21Issue(3)：67-69,3.
苦皮藤中新骨架生物碱1,3-氧氮杂环已烷化合物的抗癌活性
Anticancer Activity of The 1,3-Oxazacyclohexane Alkaloid A, B from Celastrus Angulatus
摘要
Abstract
Two new alkaloids A, B identified as 1,3-oxazacyclohexane skeleton were isolated from the seeds of Celastrus angulatus. Previous studies were focus on the sesquiterpene poloyol esters and sesquiterpene alkaloids from this family plants, which we have reported the separation and structural elucidation of two new alkaloids A, B from the same plant in recent days. Their structures were respectivily identified as 2α-(2'-pyrrolyl)-4α-methoxycarbony1-1, 3-oxazacyclohexane (A) and 2α-(2'-pyrrolyl)-4α-methoxycarbonyl-5β-[(2"-methyl)-hepty1]-1, 3-oxazacyclohexane (B). The compound B demonstrated moderate cytotoxicity against non-small lung cancer (NCL-H23) cell line by the National Cancer Institute in vitro cytotoxicity screen.关键词
苦皮藤/1,3-氧氮杂环已烷/新骨架化合物/抗癌活性Key words
Celastrus angulatus/1,3-oxazacyclohexane/New skeleton compound/Anticancer activity分类
化学化工引用本文复制引用
尹卫平,赵天增,高令杰..苦皮藤中新骨架生物碱1,3-氧氮杂环已烷化合物的抗癌活性[J].洛阳工学院学报,2000,21(3):67-69,3.基金项目
The item founded by nature sience of Sci-Tech Committee of Henan Province(974030800) （974030800）
