老年心脏病学杂志（英文版）2006，Vol.3Issue(2)：67-70,4.
Six-month results of a biodegradable polymer and rapamycin-coating stent for coronary artery disease
Six-month results of a biodegradable polymer and rapamycin-coating stent for coronary artery disease
Yuxiao ZHANG 1Caiyi LU 1Qiao XUE 1Peng LIU 1Wei YAN 1Rui CHEN1
作者信息
- 1. Institute of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China
- 折叠
摘要
Abstract
Objective To assess the safety and efficacy of a novel biodegradable polymer and rapamycin-coating stent, the EXCEL stent, in the treatment of coronary artery disease (CAD), as compared with the CypherTM stent. Methods In this prospective, non-randomized study, 60 consecutive patients with symptomatic CAD received either an EXCEL stent (n=32), or a CypherTM stent(n=28),according to their respective treatment intention. Follow-up angiography was performed at a mean of 180±40 days. The primary endpoint of the study was the occurrence of a major adverse cardiac event (MACE), including death, myocardial infarction, or target-vessel revascularization during the 6 months after stenting. The secondary end points included the in-stent late luminal loss (LLL), percentage of in-stent stenosis of the luminal diameter, and the rate of restenosis (luminal narrowing of 50 percent or more) at 6 months. Results There were no significant differences between the two groups in baseline characteristics, including the distribution of target vessel and lesion types. During the follow up period of 6 months, there were no occurrences of MACE in either group. Twenty-seven patients(84%) in the EXCEL group and 10 (36 %) in the CypherTM group underwent quantitative coronary angiography at 6 months. For these patients, no restenosis occurred, and there were no differences in the in-stent stenosis of the luminal diameter (5.98±5.52% vs 5.21 ±6.3%,P＞0.05) and the LLL (-0.02±0.09 mm vs -0.01±0.07 mm, P＞0.05). Conclusions Compared with the CypherTM stent, the EXCEL Stent with biodegradable polymer and rapamycin-coating showed similar efficacy in the prevention of neointimal proliferation, restenosis, and associated clinical events in CAD patients.关键词
coronary artery disease/stent, rapamycin/biodegradable polymerKey words
coronary artery disease/stent, rapamycin/biodegradable polymer分类
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Yuxiao ZHANG,Caiyi LU,Qiao XUE,Peng LIU,Wei YAN,Rui CHEN..Six-month results of a biodegradable polymer and rapamycin-coating stent for coronary artery disease[J].老年心脏病学杂志（英文版）,2006,3(2):67-70,4.
