首页|期刊导航|老年心脏病学杂志（英文版）|Elevated radial arterial augmentation index in hypertensive patients with diastolic dysfunction
老年心脏病学杂志（英文版）2008，Vol.5Issue(2)：67-73,7.
Elevated radial arterial augmentation index in hypertensive patients with diastolic dysfunction
Elevated radial arterial augmentation index in hypertensive patients with diastolic dysfunction
摘要
Abstract
Objective To investigate the correlation between augmentation index (AI) of the radial artery and diastolic heart function in patients with hypertension.Methods Echocardiographs were obtained for 305 patients with hypertension.AI,pulse wave velocity (PWV) of peripheral arteries and serum pro-brain natriuretic peptide (proBNP) levels were determined.Correlations and receiver operating characteristic (ROC) curves were drawn between AI values and impaired diastolic function.Results AI levels were significantly increased in patients with impaired diastolic function diagnosed by ultrasound.Assessment of diastolic heart function based on proBNP levels revealed that AI and aortic pulse wave velocity were significantly elevated in patients with impaired diastolic function.The operating curve indicated that AI may be a more accurate and efficient index for the evaluation of impaired diastolic function compared to pWV.Correlation analysis also showed that proBNP levels had altered in parallel with changes in AI and PWV.After adjusting for various factors including age,gender,blood pressure and blood lipid,a positive correlation was observed between proBNP and AI with a correlation coefficient of 0.3697 (P =0.003).However,no correlation between proBNP and aortic PWV was seen after adjustment.Conclusions Changes in radial AI levels may reflect parallel changes in diastolic cardiac function in patients with hypertension,suggesting that AI may be utilized as a non-invasive clinical indicator of diastolic heart function.关键词
augmentation index/diastolic heart failure/hypertension/pro BNP/pulse wave velocityKey words
augmentation index/diastolic heart failure/hypertension/pro BNP/pulse wave velocity分类
医药卫生引用本文复制引用
Qiang Zeng,Xiaonan Sun,Li Fan,Xinming Wang,Ping Ye..Elevated radial arterial augmentation index in hypertensive patients with diastolic dysfunction[J].老年心脏病学杂志（英文版）,2008,5(2):67-73,7.基金项目
This study was supported in part by the National High-Tech Research & Development Program (863Program) No.2006AAO2Z437 and the National NaturalSciences Foundation of China (Grant No.30570738). （863Program）
