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Inadequate glycaemic control and antidiabetic therapy among inpatients with type 2 diabetes in Guangdong Province of China

BI Yan CAI De-hong WU Ge ZHANG Fan LIN Shao-da XIAO Zheng-hua ZHU Da-long WENG Jian-ping YAN Jin-hua LIAO Zhi-hong LI Yan-bing ZENG Long-yi TANG Kuan-xiao XUE Yao-ming YANG Hua-zhang LI Lu

中华医学杂志（英文版）2008，Vol.121Issue(8)：677-681,5.

Inadequate glycaemic control and antidiabetic therapy among inpatients with type 2 diabetes in Guangdong Province of China

BI Yan ¹CAI De-hong ²WU Ge ¹ZHANG Fan ¹LIN Shao-da ¹XIAO Zheng-hua ²ZHU Da-long ¹WENG Jian-ping ³YAN Jin-hua ⁴LIAO Zhi-hong ⁵LI Yan-bing ⁶ZENG Long-yi ⁷TANG Kuan-xiao ⁸XUE Yao-ming ⁹YANG Hua-zhang ¹⁰LI Lu¹¹

作者信息

1. Department of Endocrinology, First Affiliated Hospital of Sun Yat-sen University,Guangzhou, Guangdong 510080, China
2. Department of Endocrinology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China
3. Department of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
4. Department of Endocrinology, Guangdong Provincial People's Hospital, Guangzhou, Guangdong 510080, China
5. Department of Endocrinology,Shenzhen People's Hospital,Medical College of Jinan University, Shenzhen, Guangdong 518020, China
6. Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China
7. Department of Endocrinology, Affliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, China
8. Department of Endocrinology, Pelking University Shenzhen Hospital,Shenzhen, Guangdong 518036, China
9. Department of Endocrinology, First Affiliated Hospital of Medical College of Shantou University, Shantou, Guangdong 515041, China
10. Department of Endocrinology, Guangzhou First Municipal People's Hospital, Guangzhou, Guangdong 510180, China
11. Department of Endocrinology, Drum Tower Hospital Affiliated to Medical College of Nanjing University, Nanjing, Jiangsu 210008, China
折叠

摘要

Abstract

Background Diabetes mellitus has become epidemic in recent years in China.We investigated the prevalence of hyperglycaemia and inadequate glycaemic control among type 2 diabetic inpatients from ten university teaching hospitals in Guangdong Province,China. Methods Inadequate glycaemic control in diabetic patients was defined as HbA1c(≥)6.5%.Therapeutic regimens included no-intervention,lifestyle only,oral antiglycemic agents(OA),insulin plus OA(insulin+OA),or insulin only. Antidiabetic managements included monotherapy,double therapy,triple or quadruple therapy. Results Among 493 diabetic inpatients with known history,75%had HbA1c≥6.5%.Inadequate glucose control rates were more frequently seen in patients on insulin+OA regimen(97%) than on OA regimen(71%)(P＜O.001),and more frequent in patients on combination therapy(81%-96%)than monotherapy(75%)(P＜0.05).Patients on insulin differed significantly from patients on OA by mean HbA1c,glycemic control rate,diabetes duration,microvascular complications,and BMI(P＜0.01). Conclusions This study showed that glycaemic control of type 2 diabetic patients deteriorated for patients who received insulin and initiation time of insulin was usually delayed.It is up to clinicians to move from the traditional stepwise therapy to a more active and early combination antidiabetic therapy to provide better glucose control.

关键词

type 2 diabetes/inpatient/glycaemic control/antidiabetic therapy

Key words

type 2 diabetes/inpatient/glycaemic control/antidiabetic therapy

分类

医药卫生

引用本文复制引用

BI Yan,CAI De-hong,WU Ge,ZHANG Fan,LIN Shao-da,XIAO Zheng-hua,ZHU Da-long,WENG Jian-ping,YAN Jin-hua,LIAO Zhi-hong,LI Yan-bing,ZENG Long-yi,TANG Kuan-xiao,XUE Yao-ming,YANG Hua-zhang,LI Lu..Inadequate glycaemic control and antidiabetic therapy among inpatients with type 2 diabetes in Guangdong Province of China[J].中华医学杂志（英文版）,2008,121(8):677-681,5.

基金项目

This study was supposed by the First Affiliated Hospital of Sun Yat-sen University and Special Scientitic Program from Guangdong Province(No.2006a36001001). （No.2006a36001001）

中华医学杂志（英文版）

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