中国临床康复2004，Vol.8Issue(30)：6784-6786,3.
成骨细胞和破骨细胞衰老改变及其在增龄性骨丢失中的作用
Senility changes of osteoblasts and osteoclasts and their role in aging bone loss
摘要
Abstract
BACKGROUND: The recognition of change regulation of osteoblasts and osteoclasts in the aging process, especially the biological features of osteoblasts and osteoclasts in elderly population, has quite a significant meaning for the effective and reasonable prevention of osteoporosis.OBJECTIVE: To review the experimental and clinical research result on the number and age-related activity changes of osteoblasts and osteoclasts, and to ensure the regulation and senile features of osteoblasts and osteoclasts in the duration of aging.DATA SOURCE: Articles were obtained from PubMed from 1995 to 2003,and Wanfang data base from 2002 to 2004 and study results from our laboratory.DATA EXTRACT: Sixteen PubMed articles and one from Wanfang data base, as well as data from our laboratory.MAIN OUTCOME MEASURES: Cell number, activity of enzyme andgene expression level.RESULTS: Osteoblasts and osteoclasts changed with different features in the elderly population, although their influences on bone formation and bone redecreased continuously, which presented as: decrease of cell division and proliferation ability, decrease of matrix synthesis, and weak sensibitity to Ca-regulated hormones. These changes are related with the rapid decrease of precursors in bone marrow, which caused functional deterioration due tothe tion of bone resorption function, presented as the temporary increase of osteoclasts number and mostly maintenance of its function of excreting acid and by the uncoupling of receptor activator receptor(RANKL) and osteoprotegrin (OPG)expression.CONCLUSION: The significance of activation mechanism and different bone balance caused by second flurish of osteoclasts deserves exploration. It is suggested by the author that, more attention should be paid in the basic field of precursor differentiation and proliferation in the microenvironment of bone marrow.关键词
成骨细胞/破骨细胞/增龄分类
医药卫生引用本文复制引用
高建军,金慰芳,王洪复..成骨细胞和破骨细胞衰老改变及其在增龄性骨丢失中的作用[J].中国临床康复,2004,8(30):6784-6786,3.基金项目
国家自然科学基金资助项目(39970809,30170439) （39970809,30170439）
