中国现代医学杂志2008，Vol.18Issue(6)：679-680,685,3.
肺功能检查在假肥大型进行性肌营养不良的干细胞移植治疗康复效果评定中的价值
Improvement in spirometry after stem cell transplantation on a Duchenne's muscular dystrophy patient
李志平 1钟韵 1郭禹标 1黄建强 1姚晓黎 2张成 2谢灿茂1
作者信息
- 1. 中山大学附属第一医院,呼吸内科,广东,广州,510080
- 2. 中山大学附属第一医院,神经内科,广东,广州,510080
- 折叠
摘要
Abstract
Abstract:[Objective]To describe the patterns of lung function abnormality,and to investigate the changes in spirometry before and after allogeneic hematopoietic stem cell transplantation on a Duchenne's muscular dystrophy (DMD)patient.[Methods]Lung function was measured by maximum expiratory flow-volume loops and whole body plethysmography was measured on a 14-year-old DMD patient before and three months after stem cell transplantation.[Results]Luang function test Was characterized by restrictive pattern manifested by lung volume reduction and increased FEV1/FVC due to muscular weakness.Before stem cell transplantation,the FVC,FEV1 and MVV were 1.4L, 1.4 L and 59.5 L,respectively.Three months after stem cell transplantation,the patient's FVC,FEV1 and MVV were significantly increased to 2.12 L,2.12 L and 118.00 L,respectively.[Conclusion]Although genetically modified myoblast transplantation renmins controversial for DMD,a significant change in spirometry was found in this DMD patient after stem cell transplantation.Furthermore,since DMD is characterized by gradually developing muscular weakness,pulmonary physical rehabilitation should be focused on the training of respiratory accessory muscles.关键词
肺功能/假肥大型进行性肌营养不良/干细胞移植术/康复/呼吸肌Key words
spirometry/duchenne's muscular dystrophy/stem cell transplantation/physical rehabilitation/respiratory muscle分类
医药卫生引用本文复制引用
李志平,钟韵,郭禹标,黄建强,姚晓黎,张成,谢灿茂..肺功能检查在假肥大型进行性肌营养不良的干细胞移植治疗康复效果评定中的价值[J].中国现代医学杂志,2008,18(6):679-680,685,3.
