中华医学杂志（英文版）2008，Vol.121Issue(8)：687-690,4.
Effect of Short term intensive multitherapy on Carotid intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus
Effect of Short term intensive multitherapy on Carotid intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus
GUO Li-xin 1PAN Qi 1WANG Xiao-xia 1LI Hui 1ZHANG Li-na 1CHI Jia-min 1WANG Yao1
作者信息
- 1. Department of Endocrinology,Beijing Hospital,Beijing 100730,China
- 折叠
摘要
Abstract
Background Controlling plasma glucose levels, blood pressure and lipid levels is proven to reduce the risk of vascular complications in patients with type 2 diabetes mellitus. This has prompted intensive multitherapy targeted at several macrovascular risk factors.Carotid intima-media thickness(cIMT)is a reliable measure of early atherosclerosis. We sought to determine whether a 6-month intensive mutiltherapy program resulted in better goal attainment than usual care and its effect on the development of cIMT among patients with newly diagnosed type 2 diabetes mellitus. Methods The study randomly assigned 220 patients with newly diagnosed type 2 diabetes mellitus to intensive or traditional therapy groups. The clinical parameters, such as fasting plasma glucose, total cholesterol, triglyceride, blood pressure, body weight and insulin were assessed at the baseline and after the 6-month therapy. cIMT of the patients wasalso obtained. Results The average levels of fasting plasma glucose, hemoglobin A1c, total cholesterol (TC)and low-density lipoprotein cholesterol (LDL-C)in the intensive group were significantly lower than those in the control group at the end of 6-month treatment. By 6 months, a higher proportion of patients in the intensive therapy group than in the control group attained goals for fasting plasma glucose(FPG), TC, LDL-C and hemoglobin A1c.With intensive multherapy the level of carotid intima-media thickness in the intensive therapy group was lower than that in the control group((0.88±0.26)mm vs(0.96±0.22)mm, P＜0.01).Conclusions The evidence from this clinical trial demonstrates that intensive glucose. lipid and blood pressure control in patients with newly diagnosed type 2 diabetes is associated with diabetic macrovascular benefits. Intensive multitherapy allows more patients to achieve aims of control and may reduce macrovascular complications and delay disease progression.关键词
intensive multitherapy/type 2 diabetes/carotid intima-media thicknessKey words
intensive multitherapy/type 2 diabetes/carotid intima-media thickness分类
医药卫生引用本文复制引用
GUO Li-xin,PAN Qi,WANG Xiao-xia,LI Hui,ZHANG Li-na,CHI Jia-min,WANG Yao..Effect of Short term intensive multitherapy on Carotid intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus[J].中华医学杂志（英文版）,2008,121(8):687-690,4.
