中国农业科学(英文版)2004，Vol.3Issue(9)：695-699,5.
Pharmacokinetics of Clorsulon in Sheep Following Intravenous and Subcutaneous Administration
Pharmacokinetics of Clorsulon in Sheep Following Intravenous and Subcutaneous Administration
HU Zhen-ying 1SHI Yah-bin 1ZHANG Xing-guo 1LIANG Ji-lan 1LUO Chao-ying 1LUO Yong-jiang 1SHANG Ruo-feng 1ZHENG Ji-fang 1GUO FU-cun1
作者信息
- 1. Key Laboratory of New Animal Medicine Project,Ministry of Agricultrue/Lanzhou Institute of Animal Science and Veterinary Pharmaceutics,Chinese Academy of Agricultural Sciences,Lanzhou 730050,P. R . China
- 折叠
摘要
Abstract
The study established a method to analyze clorsulon concentration in sheep plasma by reverse phase-high performance liquid chromatography(RP-HPLC)with an internal-standard.In plasma,clorsulon concentration within 0.01-1.0μgmL-1 and 1.0-20μgmL-1 ranges had a good linear relationship(R= 0.9991,0.9958). The average recovery of the method was 98.11±3.52%. The relative standard deviation(RSD)s% of within-day and between-day assays were less than 7 and 8% respectively. After giving clorsulon to sheep by intravenous(i.v.)or subcutaneous(s.c.)routes at a single dose of 4mgkg-1,drug concentration-time data in plasma were both fitted to a two-compartment open model. The main pharmacokinetic parameters were: 1)i.v. administration: T1/2β = 10.04 ± 0.819 h,area under the concentration versus time curve(AUC)=81.85±14.24mghL-1; 2)s.c. administration: T1/2ka= 1.36± 0.75 h,T1/2β=17.92 ± 9.19 h,Tmax=3.18±1.05h,Cmax=5.12±0.99μgmL-1,AUC=56.73±5.25mghL-1,F=71.03 ± 14.15%. The results indicated that clorsulon in sheep following a single s.c.administration was absorbed rapidly and eliminated slower than that following a single i.v.administration,and showed a better bioavailability.关键词
Clorsulon.Sheep.PharmacokineticsKey words
Clorsulon.Sheep.Pharmacokinetics引用本文复制引用
HU Zhen-ying,SHI Yah-bin,ZHANG Xing-guo,LIANG Ji-lan,LUO Chao-ying,LUO Yong-jiang,SHANG Ruo-feng,ZHENG Ji-fang,GUO FU-cun..Pharmacokinetics of Clorsulon in Sheep Following Intravenous and Subcutaneous Administration[J].中国农业科学(英文版),2004,3(9):695-699,5.
