中华医学杂志（英文版）2008，Vol.121Issue(8)：696-700,5.
Beta-cell dysfunction is the primary contributor to the early postpartum diabetes among Chinese women with history of gestational diabetes mellitus
Beta-cell dysfunction is the primary contributor to the early postpartum diabetes among Chinese women with history of gestational diabetes mellitus
CAO Xiao-pei 1XIAO Hai-peng 1CHEN Song-jin 1ZHAN Yan-feng 2XIU Ling-ling 1WANG Zi-lian2
作者信息
- 1. Department of Endocrinology First Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong 510080,China
- 2. Department of Obstetrics and Gynecology First Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong 510080,China
- 折叠
摘要
Abstract
Background Women with a history of gestational diabetes mellitus(GDM)are at higher risk of future development of diabetes. This study investigated the risk factors associated with early postpartum abnormal glucose regulation (AGR) among Chinese women with a history of GDM. Methods A total of 186 women with a history of GDM were screened for early postpartum AGR at 6-8 weeks after delivery. Those with AGR were given lifestyle intervention therapy and reevaluated in 6-12 months. The demographic, anthropometric, prenatal and delivery data were recorded. The plasma high-sensitivity C-reactive protein (HsCRP)and lipid concentration were measured, and insulin secretion were analyzed. Insulinogenic index △ins30'/△BG30', the homeostasis model assessment index(HOMA)-B, and HOMA-IR were calculated. Multiple regression analysis was performed to identify the risk factors. Results of the GDM women 28. O%(52/186)had AGR at 6-8 weeks after delivery;45. 2% (17/40) of these AGR women reminded abnormal after 6-12 month lifestyle intervention. Compared to the women who reverted to normal, women with consistent AGR showed significantly lower fasting insulin concentration, lower △ins30'/△BG30'as well aslower HOMA-B. No significant differences in age, body mass index(BMI), waist circumference, blood pressure, lipid level, HsCRP and HOMA-IR were observed between the two groups. Pre-pregnancy BMI＞25 kg/m2. fasting glucose level≥5. 6 mmol/L and/or 75 g oral glucose tolerance test (OGTT)2 hours glucose level≥11. 1 mmol/L during pregnancy were predictors for the AGR at 6-8 weeks after delivery. △ins30'/△BG30≤1.05 was a significant risk contributor to the consistent early postpartum AGR. Conclusion There is a high incidence of early postpartum AGR among Chinese woman with prior GDM. Beta-cell dysfunction, rather than insulin resistance or inflammation, is the predominant contributor to the early onset and consistent AGR after delivery.关键词
beta-cell function/gestational diabetes mellitus/postpartum diabetesKey words
beta-cell function/gestational diabetes mellitus/postpartum diabetes分类
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CAO Xiao-pei,XIAO Hai-peng,CHEN Song-jin,ZHAN Yan-feng,XIU Ling-ling,WANG Zi-lian..Beta-cell dysfunction is the primary contributor to the early postpartum diabetes among Chinese women with history of gestational diabetes mellitus[J].中华医学杂志（英文版）,2008,121(8):696-700,5.
