中国组织工程研究与临床康复2008，Vol.12Issue(35)：6985-6988,4.
人工髋关节无菌性松动假体周围界膜组织病理变化
Pathological changes of limiting membrane surrounding sterile artificial hip joint loosened prosthesis
王洪震 1贾正平 1徐炜 2董启榕2
作者信息
- 1. 昆山市第一医院关节外科,江苏省,昆山市,215300
- 2. 苏州大学附属第二医院骨科,江苏省,苏州市,215004
- 折叠
摘要
Abstract
BACKGROUND:Recent studies indicate that osteolysis surrounding prosthesis is the main reason causing artificial joint loosening.The reason and development process of osteolysis surrounding prosthesis are not fully understood.OBJECTIVE:To observe the pathological changes of limiting membrane surrounding sterile loosened prosthesis of artificial hip ioint and compare that with cicatricial tissue surrounding internal fixation.DESIGN,TIME AND SETTING:Histological observation was done at The Second Hospital of Soochow University between September 2000 and December 2005.PARTICIPANTS:Limiting membrane surrounding prosthesis of eight artificial hip joints overhauled for loosening were removed during operation for pathological examination.METHODS:Specimens were fixed with 10%formaldehyde solution and embedded with paraffin,and were cut into sections,the sections were stained by hematoxylin-eosin(HE)staining and immunohistochemistry staining.The specimens were done bacterial culture.MAIN OUTCOME MEASURES:Histopathological changes.RESULTS:Wear particles,cellular proliferation and osteolytic factors were found in the limiting membrane surrounding loosening prosthesis.The bacterial culture results of the specimens were negative.CONCLUSION:Wear particles generated in the using process of prosthesis can activate osteolytic factors produced by inflammatory cells and is an important reason leading to sterile loosening of prosthesis.关键词
人工关节/无菌松动/磨损颗粒分类
医药卫生引用本文复制引用
王洪震,贾正平,徐炜,董启榕..人工髋关节无菌性松动假体周围界膜组织病理变化[J].中国组织工程研究与临床康复,2008,12(35):6985-6988,4.
