天然产物研究与开发2005，Vol.17Issue(6)：700-703,4.
从中药筛选金黄色葡萄球菌耐抗菌素抑制剂
Screening of Antibiotic Resistant Inhibitors from Traditional Chinese Medicines against Two Different Strains of Staphylococcus aureus
摘要
Abstract
The present work was carried out to screen the effect of the traditional Chinese medicine in combination with the antibiotics to identify systems, which might be used to improve the efficiency of the antibiotics used. The inhibitory effects of ethanolic extracts of 14 traditional Chinese medicines and their combinations with four antibiotics on the resistance of Staphylococcus aureus were checked. Methicillin resistant S. aureus (MRSA), which was isolated from patient,and a standard strain of S. aureus were used. M. fortunei , Portulaca oleracea, M. officinalis , Platycodon grandifiorum, Leonurus heteropyllus , Prunella vulgaris were effective on improving the inhibitory effects of both the resistant and sensitive S. aureus when combined with four antibiotics. E. helioscopia , Verbena officinalis , A . carmichaeli , Plantago asiatica, Eucommia ulmoides , Datura metel showed no synergistic activity. Combinations of penicillin and ceftriaxone with Paeania lactifiora on both strains showed significant improvement in the antimicrobial activity. A. yunnanensis combined with ciprofloxacin exhibited powerful antimicrobial activity. It is a valuable practice to screen traditional Chinese medicines combined with antibiotics against S. aureus.关键词
中药/抗菌素/金黄色葡萄球菌Key words
traditional Chinese medicine/antibiotic/Staphylococcus aureus分类
农业科技引用本文复制引用
杨再昌,杨小生,王伯初,郝小江..从中药筛选金黄色葡萄球菌耐抗菌素抑制剂[J].天然产物研究与开发,2005,17(6):700-703,4.基金项目
Funded by Inno-funds for Graduates of CQU (750-411001) （750-411001）
