中德临床肿瘤学杂志（英文版）2008，Vol.7Issue(12)：701-703,3.
胃癌组织中ILK、PTEN蛋白表达的意义
The expression significance and associativity of ILK and PTEN in gastric cancer tissue
摘要
Abstract
Objective: To research the contribution of ILK and PTEN to the carcinogenesis and development of gastric carcinoma and the relation with anti-oncogene PTEN. Methods: ILK and PTEN proteins, PTEN mRNA of 76 cases of normal gastric mucous and 112 cases of gastric carcinoma were detected by immunohistochemistry method and in situ hybridization. Results: The expression of ILK, PTEN protein in gastric carcinoma group and normal gastric mucosa group, muscular layer invasive group and no muscular layer invasive group, lymphatic metastasis group and non-lymphatic metastasis group were all statistical significance (P < 0.05 or P< 0.01). The expression of PTEN mRNA of gastric carcinoma group was lower than that of normal gastric mucosa group (P < 0.01). The expression of ILK and PTEN protein had negative correlation (r = -0.347, P < 0.01). Conclusion: ILK protein increasing and PTEN protein decreasing have closely relation with the genesis and develop merit of gastric carcinoma, and controlling them may become a new treating target gastric cancer.关键词
ILK/PTEN/gastric cancerKey words
ILK/PTEN/gastric cancer分类
医药卫生引用本文复制引用
Zhou Wang ,Xuechun Wang ,Jifeng Li ,Xichao Sun ,Xu Wang..胃癌组织中ILK、PTEN蛋白表达的意义[J].中德临床肿瘤学杂志（英文版）,2008,7(12):701-703,3.基金项目
Sanitary Science and Technological Development Foun-dation of Shandong Province (2003HW015). （2003HW015）
