中国临床康复2004，Vol.8Issue(31)：7048-7049,2.
地氟烷对全脑缺血再灌注损伤大鼠超微结构的影响
Effect of desflurane on ultrastructure in rats with global cerebral ischemia-reperfusion injury
罗芳 1林捷 2孙异临 3曲宝卿3
作者信息
- 1. 首都医科大学附属北京天坛医院,麻醉科,北京市,100050
- 2. 首都医科大学附属北京天坛医院,心电图室,北京市,100050
- 3. 首都医科大学附属北京天坛医院,神经外科研究所电镜室,北京市,100050
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摘要
Abstract
BACKGROUND:Desflurane can decrease the hyponeuria of incomplete cerebral ischemia-reperfusion of rat models. But there is not enough evidence to show morphologically its brain protective effect.OBJECTIVE: To observe the influence of desflurane on the ultrastructure of global cerebral ischemia-reperfusion in rats and study its effect on brain protection.DESIGN: Randomized and controlled study.SETTING: Beijing Tiantan Hospital of Capital University of Medical Sciences.MATERIALS: The experiment was carried out in the Beijing Institute of Neurosurgery of Capital Medical University. The nine Wistar rats were randomized into 3 groups: ischemia group( n = 3), desflurane group( n = 3),and sham-operation group( n=3).INTERVENTIONS: Rat models with global cerebral ischemia-reperfusion were prapared. The desflurane inhalation for one hour was given immediately to the desflurane group when the reperfusion started. The brain was obtained one hour after the ischemia-reperfusion in the ischemia and desflurane groups and after the operation in the sham-operation group. The changes of cortical ultrastructure were observed with electron microscope.MAIN OUTCOME MEASURES: The changes of cortical ultrastructure .RESULTS: The pyknosis of neurons in thedesflurane group was less, and the organelle and microtubulo-structure were basically normal, but the gliocytes and microcirculation were not improved, as compared with those of the ischemia group .CONCLUSION: Desflurane may have protective effects on neurons and cytoskeletons, but not on the gliocytes and microcirculations.关键词
脑缺血/再灌注损伤/氟烷/神经元/超微结构分类
医药卫生引用本文复制引用
罗芳,林捷,孙异临,曲宝卿..地氟烷对全脑缺血再灌注损伤大鼠超微结构的影响[J].中国临床康复,2004,8(31):7048-7049,2.
