中国人兽共患病杂志2000，Vol.16Issue(6)：70-71,66,3.
旋毛虫感染小鼠IgG、IL-2和T淋巴细胞
亚群动态变化的观察
OBSERVATION OF THE KINETIC CHANGE ON IgG,T-CELL SUBSETS,IL-2
LEVEL OF MICE INFECTED TRICHINELLA SPIRALIS
申丽洁 1朱声华 1罗志勇1
作者信息
- 1. 大理医学院寄生虫学教研室大理，671000
华西医科大学寄生虫学教研室
大理医学院医学系
- 折叠
摘要
Abstract
Aim To explore the kinetic change of the IgG,T-cell subsets and IL-2 level from the mice infected with T. Spiralis. Methods The level of specific IgG A band IL-2 was determined by ELISA,the percentage of CD4+and CD8+ T-cells were examined by flow cytometry on 7, 14,21,28,35 days after mice infected with T. spiralis respectively. Result After infected with T. spiralis,the level of IgG in mice rised gradually,and reached its peak on the 35th day. The change of T-cell subsets showed that CD4+T cells decreased,which CD8+Tcells increased. The ration of CD4+/CD8+cells decreased,and which was the obvious on the 14thday. It did not recover to normal level even on the 35th day. The IL-2 of level reached the peak on the 7th day after infected,then IL-2 level decreased quickly and lower than that of normal mice on 35th day after infected. Conclusion When the acute phase of T. spiralis infection,the immune function of host was inhibited. The protective immunity of against T. spiralis infection was cellular immunity mainly ,in cooperation with humoral immunity.关键词
旋毛虫/IgG/T淋巴细胞亚群/IL-2Key words
T. spiralis IgG T-cell subsets IL-2分类
医药卫生引用本文复制引用
申丽洁,朱声华,罗志勇..旋毛虫感染小鼠IgG、IL-2和T淋巴细胞
亚群动态变化的观察[J].中国人兽共患病杂志,2000,16(6):70-71,66,3.
