第一军医大学学报2004，Vol.24Issue(1)：7-10,4.
促甲状腺激素受体在甲状腺相关眼病眼外肌原位表达的研究
In situ expression of thyrotropin receptor in the extraocular muscles of patients with thyroid-associated ophthalmopathy
陈静 1魏锐利 2何金 3马晓晔2
作者信息
- 1. 广州军区广州总医院眼科,广东,广州,510010
- 2. 第二军医大学长征医院,眼科,上海,200003
- 3. 第二军医大学长征医院,病理科,上海,200003
- 折叠
摘要
Abstract
Objective To investigate the expression of thyrotropin receptor (TSHR) in the extraocular muscles (EOM) of the eyes of patients with thyroid-associated ophthalmopathy (TAO). Methods EOM specimens were obtained from 12 patients with severe TAO and 10 healthy subjects within 1 hour after accidental death and the paraffin-embedded sections were observed by streptavidin-peroxidase (SP) immunohistochemical methods. Result The expression of TSHR was observed in the perimysium, cytomembrane and cytoplasm in 10 of the 12 TAO specimens, accounting for a TSHR expression rate of 83.3%in the EOM of TAO patients. No TSHR protein was found in the healthy subjects. Conclusion High TSHR expression in the EOM of TAO patients indicates that as a common antigen between the orbit and thyroid, TSHR play a key role in the pathogenesis of TAO.关键词
促甲状腺激素受体/甲状腺相关眼病/免疫组织化学Key words
thyrotropin receptor/thyroid-associated ophthalmopathy/immunohistochemitry分类
医药卫生引用本文复制引用
陈静,魏锐利,何金,马晓晔..促甲状腺激素受体在甲状腺相关眼病眼外肌原位表达的研究[J].第一军医大学学报,2004,24(1):7-10,4.
