中华医学杂志（英文版）2003，Vol.116Issue(5)：727-730,4.
Clinical significance of co-expression of VEGF-C and VEGFR-3 in non-small cell lung cancer
Clinical significance of co-expression of VEGF-C and VEGFR-3 in non-small cell lung cancer
李庆昌 1董昕 1顾伟 2邱雪杉 1王恩华1
作者信息
- 1. Department of Pathology, China Medical University, Shenyang 110001, China
- 2. Department of Pathology, First Affiliated Hospital, China Medical University, Shenyang 110001, China
- 折叠
摘要
Abstract
Objective To investigate the relationship between vascular endothelial growth factor C (VEGF-C) expression, VEGFR-3 expression, lymphangiogenesis and angiogenesis in human non-small cell lung cancer (NSCLC).Methods Seventy-six NSCLC samples were stained for VEGF-C, VEGFR-3 and CD34 with immunohistochemical methods. Assessment of lymphatic vessel density (LVD) and microvessel density (MVD) was performed. The expressions of VEGF-C in 24 fresh NSCLC samples were determined with Western blot assay.Results Of the 76 NSCLC cases, 55 were VEGF-C positive and 40 were VEGFR-3 positive in cancer cells. A significant positive correlation was found between VEGF-C expression and VEGFR-3 expression in cancer cells (P<0.05). VEGF-C expression was negatively associated with differentiation of tumor cells (P<0.05). VEGF-C expression and VEGFR-3 expression were positively associated with lymph node metastasis and lymphatic invasion (P<0.05). LVD was positively related to VEGF-C expression, lymph node metastasis, lymphatic invasion and clinical stage (P<0.05). There was a significant correlation between LVD and MVD (R=0.732, P<0.05). Patients with positive VEGF-C expression had worse outcomes than those with negative VEGF-C expression (P<0.001).Conclusions In NSCLC, VEGF-C and VEGFR-3 are related to the lymphangiogenesis, angiogenesis, and occurrence and development of lung cancers. VEGF-C expression could be a useful predictor of poor prognosis in NSCLC. 关键词
lung cancer/VEGF-C/VEGFR-3/metastasisKey words
lung cancer/VEGF-C/VEGFR-3/metastasis分类
医药卫生引用本文复制引用
李庆昌,董昕,顾伟,邱雪杉,王恩华..Clinical significance of co-expression of VEGF-C and VEGFR-3 in non-small cell lung cancer[J].中华医学杂志（英文版）,2003,116(5):727-730,4.
