中国临床康复2004，Vol.8Issue(32)：7330-7331,2.
扩张皮肤微循环变化特征及稳定血供形成时间
Microcirculation pattern of expanded skin and time for the formation of stable blood supply
王友彬 1邱玉金 1唐胜建 1戚可名 1赵敏 1宋玉萍1
作者信息
- 1. 北京协和医院整形科,北京市,100730
- 折叠
摘要
Abstract
BACKGROUND: Skin expansion is a useful method for proliferation of skin soft tissues. Its influence on microcirculation pattern of expanded skin has not been studied thoroughly so far.OBJECTIVE: To study the microcirculation pattern of expanded skin and identify the time for the formation of stable blood supply therein.DESIGN: A completely randomized auto-controlled trial.SETTING and MATERIALS: The experiment was completed in Weifang Medical College. Twenty healthy adult white rabbits with the mean body mass of 3 kg, provided by the Center for Laboratory Animals, were used as experimental animals.INTERVENTIONS: An expander was buried under the skin at the back-side of one ear, the other ear of the same rabbit was used as control. After the incision was recovered, the expander was expanded by infusion of water with equal interval. The microvessel density was measured by microcirculatory imaging system and enzyme histochemical staining.MAIN OUTCOME MEASURES: Microvessel diameter and density, blood volume, and blood velocity were observed.RESULTS: Compared with those of the contrast ear groups, all the recorded values of the experimental ears were increased obviously(all P＜0.01). The value of density was only (10.8±0.2) × 10-3 μ m2/μm2 in the unexpanded skin and that of the expanded skin showed an increase in a time-dependent manner and peaked to reached(61.1 +2.9) × 10-3μm2/μm2 4 weeks after expansion, and then began to decrease since the fifth week. In the expanded skin the microvessel diameter began to increase since 1 week after the expansion with a value of (11.162 5 ± 1.0125) μm and reached(13. 9047+1.4102) μm in the third week. The blood volume reached its highest level in the third week. The blood velocity of the expanded skin remained at a high level since the early stage of experiment.CONCLUSION: The microcirculation function is enhanced by expansion,demonstrated mainly by angiogenesis and expansion of microvessels in the early stage and then the enhanced function become stable and transforms to normal tissue microcirculation. At least one month is needed for the formation of stable blood supply.关键词
皮肤/扩张术/微循环/新生血管化,病理性分类
医药卫生引用本文复制引用
王友彬,邱玉金,唐胜建,戚可名,赵敏,宋玉萍..扩张皮肤微循环变化特征及稳定血供形成时间[J].中国临床康复,2004,8(32):7330-7331,2.
