华西医科大学学报2001，Vol.32Issue(1)：73-76,4.
尖锐湿疣Fas、bcl-2、Ki-67的表达与细胞凋亡的关系
Relationship Between Apoptosis and Expression of Fas, bcl-2 and Ki-67 in Condyloma Acuminatum
谊之张 1张敏 1王琳 1李俸媛2
作者信息
- 1. 华西医科大学附属第一医院皮肤性病科
- 2. 华西医科大学附属第一医院病理科
- 折叠
摘要
Abstract
ObjectiveThis study inquired into the significan ce and relationship of apoptosis to the regulation and proliferation of condyloma acuminatum( CA).Methods Apoptotic cells were detected in stiu by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL). The det ection of Fas, bcl 2 and Ki 67 expression was performed using immunohistochem ical staining in 28 specimens of CA. Results Apoptotic cells w ere found in 24 cases (85.7%) in keratinocytes. All of the in 28 cases（100%） had Fas and Ki 67 positive expressions, but only 8 cases（28.6%）had bcl 2 mi ld or moderate expression. The disease severity (serious, moderate and mild) groups did not significantly differ in apoptotic index (AI), Fas, bcl 2 and Ki 67 po sitive expression (P>0.05). There was positive correlation between AI and Fa s（r=0.866，P=0.000）. bcl 2 and Ki 67 were negatively correlated with AI (r=－0.416，P=0.018；r=－0.475，P=0.006). Conclusion ZIt is sugges ted that apoptosis in keratinocytes may play an important role in inhibiting th e proliferation of virus, that Fas may be an upregulative factor and bcl 2 may be an inhibition factor to apoptosis, and that excessive Ki 67 expression may be associated with the acceleration of cell cycle.关键词
尖锐湿疣 细胞凋亡 Fas bcl-2 Ki-67分类
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谊之张,张敏,王琳,李俸媛..尖锐湿疣Fas、bcl-2、Ki-67的表达与细胞凋亡的关系[J].华西医科大学学报,2001,32(1):73-76,4.
