南京农业大学学报2001，Vol.24Issue(1)：73-76,4.
糖酵解和脂肪酸氧化抑制剂对摘除卵巢猪血清促黄体素和葡萄糖的影响
Influence of inhibitors of glycolysis and fatty acid oxidation on serum concentrations of LH and glucose in ovariectomized pig
雷治海 1Barb,CR2
作者信息
- 1. 南京农业大学动物医学院,
- 2. R B Russell Agricultural Research Center,USDA,ARS,Athens,G A 30613,USA
- 折叠
摘要
Abstract
Effects of acute loss of energy availability on ser um LH and glucose concentrations were studied.Twenty crossbred gilts,(59.7± 10.2)kg BW and 120 to 130 days of age,were ovariectomized and randomly assign ed to:①saline vehicle(SAL;n＝5),400 mg*kg－1 of the glycolysis inhib itor；②2-deoxy-D-glucose(2DG,n＝5),200 mg*kg－1 of the fatty acid oxidation inhibitor；③mercaptoacetate(MA,n＝5);and ④2DG＋MA(n＝5).Blo od was sampled every 15 min for 2 h before and 6 h after treatment iv.Generally,compared to SAL,serum glucose conce ntrations were greater(P＜0.05)after 2DG and 2DG＋MA，but not after MA.2D G＋MA stimulated a greater(P＜0.01)serum glucose response than 2DG alone.R elative to the pretreatment period,2DG and 2DG＋MA suppressed LH secretion,b ut SAL and MA failed to alter LH secretion.Mean and basal serum LH concentrations were lower(P＜0.02)after 2DG and 2DG＋MA than after SAL.However,LH pulse frequency and LH pulse amplitude were unaffected by treatments.Thus energy avail ability could influence pituitary hormone secretion through a sensor within the brain.关键词
葡萄糖/促黄体素/2-脱氧-D-葡萄糖/巯基乙酸盐/猪分类
农业科技引用本文复制引用
雷治海,Barb,CR..糖酵解和脂肪酸氧化抑制剂对摘除卵巢猪血清促黄体素和葡萄糖的影响[J].南京农业大学学报,2001,24(1):73-76,4.
