广东医学2000，Vol.21Issue(9)：740-741,2.
糖尿病患者视网膜病变与降钙素基因相关肽及内皮素的关系
Relationship between diabetic retinopathy and calcitonin gene related peptide and endothelin in diabetes mellitus
苏珂 1龙艳 1胡永玲1
作者信息
- 1. 桂林医学院附属医院内分泌科(541001)
- 折叠
摘要
Abstract
Objective To study the relationship between diabetic retinopathy (DR) and calcitonin gene related peptide (CGRP)or endothelin (ET) in diabetes rnellitus. Methods The concentration of calcitonin gene related peptide and endothelin was determinedin 30 normal subjects(group C) and 60 diabetic patients(DM group) by radioimmunoassay . The DM group was sub- divided into threegroups: 20 cases of non diabetic retinopathy group (DM group Ⅰ ); 22 cases of background diabetic retinopathy group (DM group Ⅱ ); 18cases of proliferative diabetic retinopathy group (DM group Ⅲ ). Results The concentration of calcitonin gene related peptide in diabetesmellitus group was lower than that in group C( P < 0.05), the CGRP in DM group Ⅲ was markedly lower than that in group C ( P <0.01) .The development of diabetic retinopathy was associated with lower CGRP level. ET in diabetes mellitus was higher than that ingroup C, but was not significantly increased in DM group and DM group Ⅰ ( P > 0.05). The ET in DM group Ⅲ was markedly higherthan that in group C( P < 0.01). There was a positive correlation between serum EＴ and Ins in diabetes mellitus. There was a negativecorrelation between CGRP and ET in diabetes mellitus. Conclusion Depressed CGRP may be related diabetic retinopathy. Marked de-crease in CGRP and increase in ET may be associated with diabetic retinopathy.关键词
糖尿病视网膜病变/降钙素基因相关肽/内皮素Key words
Diabetic retinopathy Calcitonin gene related peptide Endothelins分类
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苏珂,龙艳,胡永玲..糖尿病患者视网膜病变与降钙素基因相关肽及内皮素的关系[J].广东医学,2000,21(9):740-741,2.
